Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | NOS2 | P35228 | 2/20 | 0.72 |
| ▸ | BLM | P54132 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | APEX1 | P27695 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | NOS3 | P29474 | 1/20 | 0.72 |
| ▸ | RECQL | P46063 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004143 | 0.88 | MAPT (0.50) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL30799054 | 0.88 | MAPT (0.50) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| 7-Nitroindazole SCHEMBL216995 | 0.85 | NOS1 (1.00) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| 7-Nitroindazole SCHEMBL4297994 | 0.83 | NOS1 (0.97) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| 7-Nitroindazole SCHEMBL4297993 | 0.83 | NOS1 (0.97) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL10594465 | 0.75 | NOS1 (0.69) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL15796932 | 0.72 | NOS1 (0.74) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL760073 | 0.71 | TDP1 (0.52) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL10595306 | 0.70 | MAPT (0.61) | NOS1MAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL499421 | 0.70 | MAPT (0.58) | NOS1MAPTKDM4EMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178870-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025478-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |