7-Nitroindazole

7-Nitroindazole

SCHEMBL216995

O=[N+]([O-])c1cccc2cn[nH]c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 6/20 1.00
MAPT P10636 4/20 1.00
TDP1 Q9NUW8 3/20 1.00
APEX1 P27695 2/20 1.00
CYP3A4 P08684 2/20 1.00
KDM4E B2RXH2 1/20 1.00
MEN1 O00255 1/20 1.00
CYP1A2 P05177 1/20 1.00
THRB P10828 1/20 1.00
HPGD P15428 1/20 1.00
TSHR P16473 1/20 1.00
NOS3 P29474 1/20 1.00
CYP2C19 P33261 1/20 1.00
NOS2 P35228 1/20 1.00
RECQL P46063 1/20 1.00
BLM P54132 1/20 1.00
KMT2A Q03164 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00
HSD17B10 Q99714 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
7-Nitroindazole SCHEMBL4297994 0.98 NOS1 (0.97) NOS1MAPTTDP1APEX1CYP3A4
7-Nitroindazole SCHEMBL4297993 0.98 NOS1 (0.97) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL15796932 0.85 NOS1 (0.74) NOS1MAPTTDP1APEX1CYP3A4
7-Nitroindazole SCHEMBL3722668 0.85 NOS1 (0.72) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL10594465 0.82 NOS1 (0.69) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL13039512 0.82 NOS1 (0.70) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL4717435 0.78 NOS1 (0.64) NOS1MAPTTDP1APEX1CYP3A4
Indazole SCHEMBL27970405 0.77 IDO1 (0.66) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL10595306 0.77 MAPT (0.61) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL11576655 0.76 NOS1 (0.61) NOS1MAPTTDP1APEX1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1272 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083844-A1 DOWNREGULATING INOS TO INCREASE CAR-T KILLING H LEE MOFFITT CANCER CT & RES (US) 2026-03-26 US claimed
EP-4709378-A1 COMPOUNDS FOR NOS-RELATED CANCERS AND METHODS OF USE Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) 2026-03-18 EP claimed
US-20250276085-A1 SYNTHETIC MULTIDOMAIN PEPTIDE BIOMATERIALS THAT INHIBIT INDUCIBLE NITRIC OXIDE SYNTHASE WILLIAM MARSH RICE UNIVERSITY (US) 2025-09-04 US claimed
US-20250255850-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) 2025-08-14 US claimed
CN-119223101-A Environment-friendly airport bird repellent bomb 中北大学 2024-12-31 CN claimed
WO-2024231899-A1 COMPOUNDS FOR NOS-RELATED CANCERS AND METHODS OF USE YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-11-14 WO claimed
WO-2024224296-A2 TARGETED PHARMACEUTICAL COMPOSITIONS TO TREAT NEUROLOGICAL CONDITIONS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-10-31 WO claimed
US-20240316006-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-09-26 US claimed
WO-2024059834-A2 DOWNREGULATING INOS TO INCREASE CAR-T KILLING H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. (US) 2024-03-21 WO claimed
WO-2023092175-A1 NOVEL P2X7 RECEPTOR ANTAGONISTS THE UNIVERSITY OF SYDNEY (AU) 2023-06-01 WO claimed
EP-0769904-A1 METHOD FOR TREATING ANXIETY Dunn, Robert W (US) 1997-05-02 EP claimed
WO-1997015280-A1 USE OF AT LEAST ONE NO SYNTHASE INHIBITOR FOR TREATING SENSITIVE SKIN L'OREAL (FR) 1997-05-01 WO claimed
EP-0765668-A1 Extract of Iridaceas and composition containing it L'OREAL (FR) 1997-04-02 EP claimed
WO-1997009032-A1 UTILIZATION OF AN EXTRACT OF A NON PHOTOSYNTHETIC FILAMENTARY BACTERIUM AND COMPOSITION CONTAINING SUCH EXTRACT L'OREAL (FR) 1997-03-13 WO claimed
WO-1997009056-A1 EXTRACT OF IRIDACEAE AND COMPOSITIONS CONTAINING SUCH EXTRACT L'OREAL (FR) 1997-03-13 WO claimed
EP-0761204-A1 Use of extracts of filamentous, non photosynthetic bacteria and the composition containing them L'OREAL (FR) 1997-03-12 EP claimed
WO-1996021445-A1 METHODS OF INHIBITING NEURODEGENERATIVE DISEASES THE GENERAL HOSPITAL CORPORATION (US) 1996-07-18 WO claimed
WO-1996002139-A1 METHOD FOR TREATING ANXIETY DUNN ROBERT W (US) 1996-02-01 WO claimed
US-5459158-A Nitric oxide synthase inhibitors; neurodegenerative diseases BURROUGHS WELLCOME CO. (US) 1995-10-17 US claimed
US-5441982-A Administering nitric oxide synthase inhibitor ITZHAK YOSSEF (US) 1995-08-15 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260083844-A1 DOWNREGULATING INOS TO INCREASE CAR-T KILLING NOS2, NOS1, NOS3 NOS1 2/4885MAPT 2165/4885TDP1 2862/4885
US-20240316006-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS NLN, ACHE, SMN1; SMN2 NOS1 28/4885MAPT 33/4885TDP1 599/4885
US-20250255850-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING NEUROLOGICAL CONDITIONS NLN, ACHE, PYGB NOS1 18/4885MAPT 40/4885TDP1 567/4885
US-20250276085-A1 SYNTHETIC MULTIDOMAIN PEPTIDE BIOMATERIALS THAT INHIBIT INDUCIBLE NITRIC OXIDE SYNTHASE STING1, CGAS, GMPS NOS1 4/4885MAPT 4516/4885TDP1 297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.