7-Nitroindazole

7-Nitroindazole

SCHEMBL4297994

O=[N+]([O-])c1cccc2cn[nH]c12.[Na]

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 6/20 0.97
MAPT P10636 4/20 0.97
TDP1 Q9NUW8 3/20 0.97
APEX1 P27695 2/20 0.97
CYP3A4 P08684 2/20 0.97
KDM4E B2RXH2 1/20 0.97
MEN1 O00255 1/20 0.97
CYP1A2 P05177 1/20 0.97
THRB P10828 1/20 0.97
HPGD P15428 1/20 0.97
TSHR P16473 1/20 0.97
NOS3 P29474 1/20 0.97
CYP2C19 P33261 1/20 0.97
NOS2 P35228 1/20 0.97
RECQL P46063 1/20 0.97
BLM P54132 1/20 0.97
KMT2A Q03164 1/20 0.97
SMN1; SMN2 Q16637 1/20 0.97
NPSR1 Q6W5P4 1/20 0.97
HSD17B10 Q99714 1/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
7-Nitroindazole SCHEMBL216995 0.98 NOS1 (1.00) NOS1MAPTTDP1APEX1CYP3A4
7-Nitroindazole SCHEMBL4297993 0.97 NOS1 (0.97) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL15796932 0.84 NOS1 (0.74) NOS1MAPTTDP1APEX1CYP3A4
7-Nitroindazole SCHEMBL3722668 0.83 NOS1 (0.72) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL10594465 0.81 NOS1 (0.69) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL13039512 0.81 NOS1 (0.70) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL4717435 0.77 NOS1 (0.64) NOS1MAPTTDP1APEX1CYP3A4
Indazole SCHEMBL27970405 0.76 IDO1 (0.66) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL10595306 0.75 MAPT (0.61) NOS1MAPTTDP1APEX1CYP3A4
SCHEMBL11576655 0.75 NOS1 (0.61) NOS1MAPTTDP1APEX1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090269281-A1 Calcium/Calmodulin-Dependent Protein Kinase Kinase as a Control Point for Cardiac Hypertrophy UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (US) 2009-10-29 US claimed
US-20090269281-A1 Calcium/Calmodulin-Dependent Protein Kinase Kinase as a Control Point for Cardiac Hypertrophy UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (US) 2009-10-29 US disclosed
EP-1638931-A4 METHOD OF TARGETING A THERAPEUTIC AGENT NEUROMOLECULAR INC (US) 2007-11-07 EP disclosed
EP-1638931-A2 METHOD OF TARGETING A THERAPEUTIC AGENT Neuromolecular Inc. (US) 2006-03-29 EP disclosed
US-20050124701-A1 Method of targeting a therapeutic agent NEUROMOLECULAR, INC. 2005-06-09 US disclosed
WO-2005019166-A2 METHOD OF TARGETING A THERAPEUTIC AGENT NEUROMOLECULAR, INC. (US) 2005-03-03 WO disclosed
WO-2002031189-A2 MODEL SYSTEM FOR THE VIVO STUDY OF APOPTOSIS EIRX THERAPEUTIC LIMITED (IE) 2002-04-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050124701-A1 Method of targeting a therapeutic agent GAP43, CHAT, NEFM NOS1 3978/4885MAPT 226/4885TDP1 1242/4885
US-20090269281-A1 Calcium/Calmodulin-Dependent Protein Kinase Kinase as a Control Point for Cardiac Hypertrophy CAMK4, CAMKK2, CAMK1 NOS1 1824/4885MAPT 2984/4885TDP1 3790/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.