Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.97 |
| ▸ | MAPT | P10636 | 4/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.97 |
| ▸ | APEX1 | P27695 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | THRB | P10828 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | NOS3 | P29474 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | NOS2 | P35228 | 1/20 | 0.97 |
| ▸ | RECQL | P46063 | 1/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 7-Nitroindazole SCHEMBL216995 | 0.98 | NOS1 (1.00) | NOS1MAPTTDP1APEX1CYP3A4 | |
| 7-Nitroindazole SCHEMBL4297994 | 0.97 | NOS1 (0.97) | NOS1MAPTTDP1APEX1CYP3A4 | |
| SCHEMBL15796932 | 0.84 | NOS1 (0.74) | NOS1MAPTTDP1APEX1CYP3A4 | |
| 7-Nitroindazole SCHEMBL3722668 | 0.83 | NOS1 (0.72) | NOS1MAPTTDP1APEX1CYP3A4 | |
| SCHEMBL10594465 | 0.81 | NOS1 (0.69) | NOS1MAPTTDP1APEX1CYP3A4 | |
| SCHEMBL13039512 | 0.81 | NOS1 (0.70) | NOS1MAPTTDP1APEX1CYP3A4 | |
| SCHEMBL4717435 | 0.77 | NOS1 (0.64) | NOS1MAPTTDP1APEX1CYP3A4 | |
| Indazole SCHEMBL27970405 | 0.76 | IDO1 (0.66) | NOS1MAPTTDP1APEX1CYP3A4 | |
| SCHEMBL10595306 | 0.75 | MAPT (0.61) | NOS1MAPTTDP1APEX1CYP3A4 | |
| SCHEMBL11576655 | 0.75 | NOS1 (0.61) | NOS1MAPTTDP1APEX1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090269281-A1 | Calcium/Calmodulin-Dependent Protein Kinase Kinase as a Control Point for Cardiac Hypertrophy | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (US) | 2009-10-29 | — | — | US | claimed |
| US-20090269281-A1 | Calcium/Calmodulin-Dependent Protein Kinase Kinase as a Control Point for Cardiac Hypertrophy | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (US) | 2009-10-29 | — | — | US | disclosed |
| EP-1638931-A4 | METHOD OF TARGETING A THERAPEUTIC AGENT | NEUROMOLECULAR INC (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1638931-A2 | METHOD OF TARGETING A THERAPEUTIC AGENT | Neuromolecular Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050124701-A1 | Method of targeting a therapeutic agent | NEUROMOLECULAR, INC. | 2005-06-09 | — | — | US | disclosed |
| WO-2005019166-A2 | METHOD OF TARGETING A THERAPEUTIC AGENT | NEUROMOLECULAR, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2002031189-A2 | MODEL SYSTEM FOR THE VIVO STUDY OF APOPTOSIS | EIRX THERAPEUTIC LIMITED (IE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124701-A1 | Method of targeting a therapeutic agent | GAP43, CHAT, NEFM | NOS1 3978/4885MAPT 226/4885TDP1 1242/4885 |
| US-20090269281-A1 | Calcium/Calmodulin-Dependent Protein Kinase Kinase as a Control Point for Cardiac Hypertrophy | CAMK4, CAMKK2, CAMK1 | NOS1 1824/4885MAPT 2984/4885TDP1 3790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.