Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372557 | 0.86 | KMT2A (0.53) | KDM4EKMT2ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL232458 | 0.83 | PDGFRB (0.65) | KDM4EKMT2ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL27600512 | 0.82 | PDGFRB (0.62) | KDM4EKMT2ASMN1; SMN2ALDH1A1GAA | |
| Iodide SCHEMBL31463336 | 0.82 | PDGFRB (0.62) | KDM4EKMT2ASMN1; SMN2ALDH1A1GAA | |
| Bromide SCHEMBL8728376 | 0.82 | PDGFRB (0.62) | KDM4EKMT2ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL28205439 | 0.82 | PDGFRB (0.62) | KDM4EKMT2ASMN1; SMN2ALDH1A1GAA | |
| 2-Naphthaldehyde SCHEMBL434215 | 0.80 | RAB9A (0.47) | KDM4ESMN1; SMN2ALDH1A1GAARAB9A | |
| Benzaldehyde SCHEMBL367504 | 0.75 | ALDH1A1 (0.54) | KMT2AALDH1A1MEN1NPC1LMNA | |
| Guanidine SCHEMBL27886366 | 0.75 | RAB9A (0.55) | KDM4EKMT2ASMN1; SMN2ALDH1A1GAA | |
| Quinoline SCHEMBL1848150 | 0.74 | ALDH1A1 (0.59) | KDM4EKMT2ASMN1; SMN2ALDH1A1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4724337-B2 | — | — | 2011-07-13 | — | — | JP | claimed |
| US-20060128962-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ALLEN MICHAEL S | 2006-06-15 | — | — | US | claimed |
| US-20030199696-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2003-10-23 | — | — | US | claimed |
| JP-2003503388-A | — | — | 2003-01-28 | — | — | JP | claimed |
| US-20020165390-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2002-11-07 | — | — | US | claimed |
| EP-1192139-A1 | PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES | Abbott Laboratories (US) | 2002-04-03 | — | — | EP | claimed |
| US-20020013468-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | ABBVIE INC. | 2002-01-31 | — | — | US | claimed |
| WO-2001000582-A1 | PREPARATION OF QUINOLINE-SUBSTITUTED CARBONATE AND CARBAMATE DERIVATIVES | ABBOTT LABORATORIES (US) | 2001-01-04 | — | — | WO | claimed |
| EP-2409964-A2 | Preparation of substituted carbonate and carbamate derivatives | Abbott Laboratories (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2261212-A2 | Preparation of quinoline-substituted carbonate and carbamate derivatives | Abbott Laboratories (US) | 2010-12-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128962-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | KDM4E 211/4885KMT2A 567/4885SMN1; SMN2 4246/4885 |
| US-20030199696-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | KDM4E 211/4885KMT2A 567/4885SMN1; SMN2 4246/4885 |
| US-20020165390-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | KDM4E 211/4885KMT2A 567/4885SMN1; SMN2 4246/4885 |
| US-20020013468-A1 | Preparation of quinoline-substituted carbonate and carbamate derivatives | CA7, CA6, CA4 | KDM4E 211/4885KMT2A 567/4885SMN1; SMN2 4246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.