Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724391 | 0.87 | HDAC1 (0.42) | POLQKDM4EHDAC1HDAC7KMT2A | |
| SCHEMBL3725282 | 0.87 | KMT2A (0.41) | POLQKDM4EHDAC1HDAC7KMT2A | |
| SCHEMBL3724975 | 0.86 | KDM4E (0.45) | KDM4EHDAC1HDAC7KMT2ASMN1; SMN2 | |
| SCHEMBL13260110 | 0.84 | KDM4E (0.43) | POLQKDM4EHDAC1HDAC7KMT2A | |
| SCHEMBL3722206 | 0.83 | POLQ (0.52) | POLQKDM4EKMT2ASMN1; SMN2CREBBP | |
| SCHEMBL3725838 | 0.75 | KDM4E (0.45) | KDM4EHDAC1HDAC7KMT2ASMN1; SMN2 | |
| SCHEMBL3725819 | 0.75 | HDAC1 (0.42) | KDM4EHDAC1HDAC7KMT2ASMN1; SMN2 | |
| SCHEMBL3724299 | 0.74 | POLQ (0.50) | POLQKDM4EKMT2ASMN1; SMN2POLB | |
| SCHEMBL3721607 | 0.73 | KDM4E (0.43) | KDM4EHDAC1HDAC7KMT2ASMN1; SMN2 | |
| SCHEMBL13260951 | 0.71 | KDM4E (0.40) | KDM4EKMT2ASMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |