Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13260110 | 0.89 | KDM4E (0.43) | KDM4EKMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL3725282 | 0.86 | KMT2A (0.41) | KDM4EKMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL3724448 | 0.86 | POLQ (0.41) | KDM4EKMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL3722206 | 0.83 | POLQ (0.52) | KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL3725838 | 0.80 | KDM4E (0.45) | KDM4EKMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL3725819 | 0.80 | HDAC1 (0.42) | KDM4EKMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14343247 | 0.78 | KDM4E (0.46) | KDM4EKMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3721607 | 0.78 | KDM4E (0.43) | KDM4EKMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL720425 | 0.76 | KLKB1 (0.53) | KMT2ASMN1; SMN2ALDH1A1POLBFFAR4 | |
| SCHEMBL3724299 | 0.75 | POLQ (0.50) | KDM4EKMT2ASMN1; SMN2POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |