SCHEMBL3724712

SCHEMBL3724712

NCc1cc(-c2ccc(F)c(Cl)c2)nc(N2CCN(c3ccccc3F)CC2)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.42
SMN1; SMN2 Q16637 4/20 0.42
ALDH1A1 P00352 3/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 4/20 0.40
POLB P06746 2/20 0.40
TP53 P04637 1/20 0.40
MAPK1 P28482 1/20 0.39
MDM2 Q00987 1/20 0.38
HTT P42858 2/20 0.37
ABCB1 P08183 1/20 0.37
ABCG2 Q9UNQ0 1/20 0.37
AXL P30530 1/20 0.37
DRD2 P14416 1/20 0.37
DRD4 P21917 1/20 0.37
DRD3 P35462 1/20 0.37
GAA P10253 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3717916 0.94 LMNA (0.42) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3721161 0.91 MAPT (0.44) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3726353 0.89 ALDH1A1 (0.44) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3727042 0.87 DRD2 (0.47) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3718590 0.87 ALDH1A1 (0.52) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3726395 0.85 LMNA (0.41) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3721778 0.85 SMN1; SMN2 (0.46) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3721047 0.84 SMN1; SMN2 (0.45) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3721920 0.84 LMNA (0.52) LMNASMN1; SMN2ALDH1A1NPC1MAPT
SCHEMBL3725556 0.83 ABCB1 (0.56) LMNASMN1; SMN2ALDH1A1NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US claimed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO claimed
US-8614201-B2 Heterocyclic amides as modulators of TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2013-12-24 US disclosed
WO-2010141805-A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 JANSSEN PHARMACEUTICA NV (BE) 2010-12-09 WO disclosed