Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718958 | 0.91 | ACACB (0.39) | LMNANPSR1PDK2NPC1RAB9A | |
| SCHEMBL3728740 | 0.88 | L3MBTL1 (0.36) | LMNANPSR1NPC1RAB9AKCNH2 | |
| SCHEMBL1220435 | 0.88 | MAPT (0.41) | LMNANPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL3723404 | 0.85 | GPR3 (0.37) | NPC1RAB9AKCNH2SCN9A | |
| SCHEMBL3717968 | 0.85 | MAOB (0.41) | NPC1RAB9AKCNH2MAPTL3MBTL1 | |
| SCHEMBL3716786 | 0.84 | PDK2 (0.40) | PDK2NPC1RAB9AKCNH2SCN9A | |
| SCHEMBL3721862 | 0.81 | CACNA1G (0.42) | NPC1RAB9AKCNH2MAPTKMT2A | |
| SCHEMBL542216 | 0.80 | KCNH2 (0.42) | NPC1RAB9AKCNH2AR | |
| SCHEMBL1220445 | 0.79 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL1437847 | 0.79 | PDK2 (0.41) | LMNANPSR1PDK2KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010081149-A1 | ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | GLAXOSMITHKLINE LLC (US) | 2010-07-15 | — | — | WO | disclosed |