Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31390710 | 0.70 | MEN1 (0.43) | SMN1; SMN2KDM4EHTTKMT2AMEN1 | |
| SCHEMBL1128054 | 0.63 | HDAC3 (0.48) | SMN1; SMN2KDM4EHTTKMT2AADRA1D | |
| SCHEMBL24886037 | 0.63 | CYP2D6 (0.58) | SMN1; SMN2KDM4EKMT2AHSD17B3MEN1 | |
| SCHEMBL29642368 | 0.63 | KDM4E (0.58) | SMN1; SMN2KDM4EHTTKMT2AMEN1 | |
| SCHEMBL179103 | 0.63 | KDM4E (0.58) | SMN1; SMN2KDM4EHTTKMT2AMEN1 | |
| SCHEMBL1649346 | 0.61 | MAOA (0.56) | SMN1; SMN2KDM4EHTTKMT2AADRA1D | |
| SCHEMBL7960264 | 0.61 | HTR6 (0.41) | KMT2AMAPK1TDP1ALDH1A1 | |
| SCHEMBL682960 | 0.61 | ALDH1A1 (0.55) | SMN1; SMN2KDM4EADRA1DADRA1AADRA1B | |
| SCHEMBL32082017 | 0.61 | ALDH1A1 (0.55) | SMN1; SMN2KDM4EADRA1DADRA1AADRA1B | |
| SCHEMBL14611985 | 0.60 | CA12 (0.47) | SMN1; SMN2KDM4EHTTKMT2AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138589-A1 | BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-02 | — | — | WO | disclosed |