Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 15/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 15/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725063 | 0.89 | ROCK2 (0.41) | GPR35ROCK2ROCK1POLQ | |
| SCHEMBL3724691 | 0.81 | GPR35 (0.52) | GPR35ROCK2ROCK1MTORPOLQ | |
| SCHEMBL3725804 | 0.78 | DAO (0.46) | GPR35ROCK2ROCK1AKT1 | |
| SCHEMBL13260952 | 0.77 | ROCK2 (0.39) | GPR35ROCK2ROCK1POLQ | |
| SCHEMBL1802291 | 0.76 | PLAU (0.47) | — | |
| SCHEMBL3730621 | 0.74 | DAO (0.36) | — | |
| SCHEMBL25349742 | 0.70 | MAPK14 (0.37) | — | |
| SCHEMBL3724785 | 0.69 | ROCK2 (0.42) | GPR35ROCK2ROCK1POLQ | |
| SCHEMBL2323109 | 0.69 | L3MBTL1 (0.53) | — | |
| SCHEMBL1529951 | 0.69 | ALDH1A1 (0.34) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |