Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MGAT2 | Q10469 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725869 | 0.92 | MEN1 (0.42) | MEN1MAPK1KMT2AMAPTBDKRB1 | |
| SCHEMBL3722079 | 0.89 | CNR1 (0.37) | BDKRB1GAA | |
| SCHEMBL3728527 | 0.84 | MEN1 (0.42) | MEN1MAPK1KMT2AMAPTBDKRB1 | |
| SCHEMBL3722367 | 0.83 | BDKRB1 (0.46) | MEN1MAPK1KMT2ABDKRB1 | |
| SCHEMBL3722724 | 0.83 | MEN1 (0.36) | MEN1KMT2ABDKRB1NPC1RAB9A | |
| SCHEMBL3721992 | 0.82 | BDKRB1 (0.35) | BDKRB1GAAMAPK8MAPK10 | |
| SCHEMBL3722860 | 0.81 | GAA (0.33) | GAAP2RX7MAPK8MAPK10 | |
| SCHEMBL12238935 | 0.81 | MEN1 (0.46) | MEN1MAPK1KMT2ABDKRB1KDM4E | |
| SCHEMBL3718253 | 0.79 | GAA (0.33) | MEN1KMT2AMAPTKDM4EGAA | |
| SCHEMBL3725868 | 0.79 | MEN1 (0.41) | MEN1MAPK1KMT2ABDKRB1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097373-A1 | COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |