Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24339049 | 0.81 | L3MBTL1 (0.40) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL3889500 | 0.79 | L3MBTL1 (0.44) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL2579028 | 0.79 | ALDH1A1 (0.52) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL1427356 | 0.78 | TDP1 (0.42) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL3964969 | 0.78 | TDP1 (0.65) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL3642887 | 0.77 | NPC1 (0.52) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL30316868 | 0.76 | KDM4C (0.53) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL229353 | 0.76 | KDM4C (0.53) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL2905999 | 0.75 | ALDH1A1 (0.44) | TDP1SIRT3L3MBTL1ALDH1A1GAA | |
| SCHEMBL1135627 | 0.75 | SIRT3 (0.60) | TDP1SIRT3L3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132016-A1 | BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |