Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839581 | 0.79 | ROCK2 (0.49) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL3731616 | 0.79 | TDP1 (0.42) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL24339049 | 0.79 | L3MBTL1 (0.40) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL30849093 | 0.76 | TDP1 (0.46) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL16414200 | 0.76 | TDP1 (0.46) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL27794274 | 0.74 | KMT2A (0.54) | L3MBTL1ALDH1A1KDM4EGAATDP1 | |
| SCHEMBL229353 | 0.74 | KDM4C (0.53) | L3MBTL1ALDH1A1KDM4EGAASIRT3 | |
| SCHEMBL30316868 | 0.74 | KDM4C (0.53) | L3MBTL1ALDH1A1KDM4EGAASIRT3 | |
| SCHEMBL30316842 | 0.73 | L3MBTL1 (0.40) | L3MBTL1ALDH1A1KDM4EGLAGAA | |
| SCHEMBL25236818 | 0.73 | L3MBTL1 (0.40) | L3MBTL1ALDH1A1KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010493-A2 | PYRIDYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120729-A2 | PYRIDYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-10-25 | — | — | WO | disclosed |