Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718345 | 0.93 | TSHR (0.34) | TSHRMAPK1LMNA | |
| SCHEMBL3726723 | 0.87 | TSHR (0.40) | TSHRMAPK1LMNA | |
| SCHEMBL13041035 | 0.86 | LMNA (0.35) | TSHRMAPK1LMNA | |
| SCHEMBL9456178 | 0.86 | TSHR (0.38) | TSHRMAPK1LMNA | |
| SCHEMBL9238798 | 0.84 | TSHR (0.39) | TSHRMAPK1LMNA | |
| SCHEMBL9787529 | 0.80 | POLB (0.33) | LMNA | |
| SCHEMBL8906827 | 0.79 | ALDH1A1 (0.38) | LMNA | |
| SCHEMBL8743099 | 0.79 | ALDH1A1 (0.40) | TSHRMAPK1LMNA | |
| SCHEMBL8905904 | 0.77 | LIMK1 (0.36) | LMNA | |
| SCHEMBL12871730 | 0.77 | TSHR (0.40) | TSHRMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680334-B2 | Process for the preparation of iosimenol | MALLINCKRODT LLC (US) | 2014-03-25 | — | — | US | disclosed |
| US-20130261338-A1 | Process for the Preparation of Iosimenol | MALLINCKRODT LLC (US) | 2013-10-03 | — | — | US | disclosed |
| US-8445725-B2 | Process for the preparation of iosimenol | MALLINCKRODT LLC (US) | 2013-05-21 | — | — | US | disclosed |
| EP-2240432-B1 | PROCESS FOR THE PREPARATION OF IOSIMENOL | MALLINCKRODT LLC (US) | 2012-07-04 | — | — | EP | disclosed |
| US-20100280270-A1 | Process for the Prepartion of Iosimenol | MNK 2011 LLC (F/K/A MALLINCKRODT INC.) | 2010-11-04 | — | — | US | disclosed |
| EP-2240432-A1 | PROCESS FOR THE PREPARATION OF IOSIMENOL | Mallinckrodt Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009091758-A1 | PROCESS FOR THE PREPARATION OF IOSIMENOL | MALLINCKRODT INC. (US) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280270-A1 | Process for the Prepartion of Iosimenol | DHCR24, DRD4, NONO | TSHR 1558/4885MAPK1 672/4885LMNA 713/4885 |
| US-20130261338-A1 | Process for the Preparation of Iosimenol | ITPR3, ITPR2, DHCR24 | TSHR 1304/4885MAPK1 773/4885LMNA 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.