Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 9/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3733737 | 0.76 | CA1 (0.38) | — | |
| SCHEMBL3935992 | 0.71 | GRIN2B (0.47) | GRIN2BCYP2D6CXCR4EPHX2 | |
| SCHEMBL30791537 | 0.71 | POLB (0.66) | FAAHGRIN2BTRPV1PDGFRBCYP2D6 | |
| SCHEMBL1758868 | 0.71 | POLB (0.66) | FAAHGRIN2BTRPV1PDGFRBCYP2D6 | |
| Hydrochloric Acid SCHEMBL2194067 | 0.70 | POLB (0.68) | FAAHGRIN2BTRPV1PDGFRBCYP2D6 | |
| SCHEMBL5334736 | 0.70 | MAPK1 (0.39) | FAAH | |
| SCHEMBL15529643 | 0.67 | TRPV1 (0.60) | FAAHGRIN2BTRPV1PDGFRBHTR2C | |
| SCHEMBL780721 | 0.66 | GPR119 (0.48) | GRIN2BCYP2D6 | |
| SCHEMBL3933150 | 0.66 | GRIN2B (0.46) | GRIN2BEPHX2 | |
| SCHEMBL1960679 | 0.66 | TRPV1 (0.58) | FAAHGRIN2BTRPV1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836179-A1 | PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006074025-A1 | PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |