Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PRLHR | P49683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623255 | 0.90 | CKS1B (0.38) | HTR2CHTR2B | |
| SCHEMBL14043887 | 0.73 | ADRB2 (0.36) | HTR2CHTR2BPDE10A | |
| SCHEMBL14043965 | 0.72 | GPR119 (0.34) | PDE10A | |
| SCHEMBL19894405 | 0.70 | DPP4 (0.36) | — | |
| SCHEMBL1621294 | 0.70 | RORC (0.38) | — | |
| SCHEMBL1623132 | 0.70 | CKS1B (0.37) | HTR2CHTR2B | |
| SCHEMBL4696960 | 0.70 | PDK2 (0.36) | LMNA | |
| SCHEMBL19617362 | 0.70 | KMT2A (0.34) | TRPV1 | |
| SCHEMBL4695273 | 0.69 | KCNK3 (0.45) | LMNA | |
| SCHEMBL1621232 | 0.69 | OPRD1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139896-A1 | PYRIMIDO [4, 5-D]AZEPINE DERIVATIVES AS 5-HT2C AGONISTS | Pfizer Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008117169-A1 | PYRIMIDO [4, 5-D] AZEPINE DERIVATIVES AS 5-HT2C AGONISTS | PFIZER LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |