SCHEMBL373699

SCHEMBL373699

C=C(C)C(=O)OCCN(CC)c1ccc(N=Nc2c(O)ccc(C(=O)c3ccccc3)c2O)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.36
KMT2A Q03164 4/20 0.36
SMN1; SMN2 Q16637 4/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
ESRRG P62508 1/20 0.35
MAPT P10636 6/20 0.33
ALDH1A1 P00352 5/20 0.33
KDM4E B2RXH2 4/20 0.33
ALOX15 P16050 3/20 0.33
HSD17B10 Q99714 3/20 0.33
HPGD P15428 3/20 0.33
RECQL P46063 2/20 0.33
ALOX12 P18054 1/20 0.33
PPARG P37231 1/20 0.33
MAOB P27338 1/20 0.33
MAPK1 P28482 2/20 0.33
ELANE P08246 1/20 0.33
CNR2 P34972 1/20 0.32
LMNA P02545 3/20 0.32
HTT P42858 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL373512 0.87 MAPT (0.33) MEN1KMT2ASMN1; SMN2L3MBTL1MAPT
SCHEMBL23406875 0.85 ESRRG (0.36) MEN1KMT2ASMN1; SMN2L3MBTL1ESRRG
SCHEMBL373548 0.85 LMNA (0.36) MEN1KMT2ASMN1; SMN2L3MBTL1ESRRG
SCHEMBL15357901 0.83 RAB9A (0.41) MEN1KMT2ASMN1; SMN2L3MBTL1ESRRG
SCHEMBL373198 0.83 MAPT (0.35) MEN1KMT2ASMN1; SMN2L3MBTL1MAPT
SCHEMBL373331 0.83 PPARG (0.38) MEN1KMT2ASMN1; SMN2L3MBTL1MAPT
SCHEMBL373513 0.81 PPARG (0.39) MEN1KMT2AL3MBTL1MAPTALDH1A1
SCHEMBL373839 0.81 ALDH1A1 (0.41) MEN1KMT2ASMN1; SMN2L3MBTL1MAPT
SCHEMBL7174763 0.81 ALDH1A1 (0.41) MEN1KMT2ASMN1; SMN2L3MBTL1MAPT
SCHEMBL373700 0.80 MEN1 (0.35) MEN1KMT2ASMN1; SMN2L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-112703213-A Polymer material 株式会社目立康 2021-04-23 CN disclosed
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 US disclosed
EP-3086163-B1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME MENICON CO LTD (JP) 2018-11-14 EP disclosed
EP-2857459-B1 STABLE POLYMERIZABLE UV-ABSORBING COLORANT FOR INTRAOCULAR LENS KOWA CO (JP) 2017-12-27 EP disclosed
US-9657131-B2 Ophthalmic lens MENICON CO., LTD. (JP) 2017-05-23 US disclosed
US-9650473-B2 Polysiloxane-based macromonomer for ophthalmic lens and ophthalmic lens using the same MENICON CO., LTD. (JP) 2017-05-16 US disclosed
EP-2330161-B1 DYE COMPOSITION FOR OPHTHALMIC LENS, METHOD FOR PRODUCING COLORED OPHTHALMIC LENS USING THE SAME AND COLORED OPHTHALMIC LENS MENICON CO LTD (JP) 2017-01-25 EP disclosed
EP-3086162-A1 OCULAR LENS Menicon Co., Ltd. (JP) 2016-10-26 EP disclosed
EP-0379146-B1 Soft ocular lens material MENICON CO LTD (JP) 1995-05-17 EP disclosed
US-5416132-A Acrylamide modified acrylate modified polysiloxanes MENICON CO., LTD. (JP) 1995-05-16 US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 US disclosed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 EP disclosed
US-5041511-A Vinyl benzene acrylate or methacrylate crosslinking agent MENICON CO., LTD. (JP) 1991-08-20 US disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 US disclosed