Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 11/20 | 0.39 |
| ▸ | DRD2 | P14416 | 10/20 | 0.39 |
| ▸ | HTR1A | P08908 | 8/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 2/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275976 | 0.83 | GPR119 (0.49) | — | |
| SCHEMBL20139993 | 0.82 | DRD2 (0.54) | DRD4DRD2HTR1AKDM5AUBE2M | |
| SCHEMBL29556164 | 0.77 | CNR2 (0.41) | DRD4DRD2HTR1AKDM5AUBE2M | |
| SCHEMBL15140526 | 0.77 | CNR2 (0.41) | DRD4DRD2HTR1AKDM5AUBE2M | |
| SCHEMBL20266326 | 0.76 | UBE2M (0.41) | DRD4DRD2HTR1AKDM5AUBE2M | |
| SCHEMBL29924785 | 0.76 | UBE2M (0.41) | DRD4DRD2HTR1AKDM5AUBE2M | |
| SCHEMBL9943901 | 0.76 | CNR2 (0.49) | DRD4DRD2HTR1AKDM5AUBE2M | |
| SCHEMBL29668662 | 0.76 | HTR1A (0.50) | DRD4DRD2HTR1AKDM5AUBE2M | |
| SCHEMBL274852 | 0.76 | PIM1 (0.48) | — | |
| SCHEMBL21597925 | 0.76 | HTR1A (0.53) | DRD4DRD2HTR1AUBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825119-B2 | Bone disorders such as osteoporosis, tumors and cardiovascular disorders; 4-(2-carboxy-2-Boc-aminoethylamino)-6-piperidinopyrimidines such as tert-butyl 2-benzyloxycarbonylamino-3-[2,5-dimethoxy-6-(4-[1,8]naphthyridin-2-yl-piperidin-1-yl)pyrimidin-4-ylamino]-propionate | GALAPAGOS SAS (FR) | 2010-11-02 | — | — | US | disclosed |