Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263669 | 0.98 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL858370 | 0.80 | ALDH1A1 (0.51) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL30424732 | 0.80 | ALDH1A1 (0.51) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL1256865 | 0.79 | CA2 (0.54) | MAPTALDH1A1POLBTSHRKDM4E | |
| SCHEMBL29419589 | 0.77 | CA2 (0.56) | MAPTALDH1A1POLBTSHRKDM4E | |
| SCHEMBL20509 | 0.77 | CA2 (0.56) | MAPTALDH1A1POLBTSHRKDM4E | |
| SCHEMBL15969085 | 0.76 | HPGD (0.42) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL30214873 | 0.76 | HPGD (0.42) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL1129397 | 0.76 | MAPT (0.48) | MAPTALDH1A1GAAPOLBRECQL | |
| SCHEMBL2878953 | 0.75 | CSNK2A1 (0.43) | MAPTALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
| US-7026515-B2 | Optically active amine derivatives and preparation process therefor | MITSUI CHEMICALS, INC. (JP) | 2006-04-11 | — | — | US | disclosed |
| US-6875866-B2 | Process for synthesis of D1 receptor antagonists | SCHERING CORPORATION (US) | 2005-04-05 | — | — | US | disclosed |
| US-20040030144-A1 | Optically active amine derivative and method of synthesis | MITSUI CHEMICALS, INC. (JP) | 2004-02-12 | — | — | US | disclosed |
| US-20030199690-A1 | Process for synthesis of D1 receptor antagonists | SCHERING CORPORATION | 2003-10-23 | — | — | US | disclosed |
| EP-1340743-A1 | OPTICALLY ACTIVE AMINE DERIVATIVE AND METHOD OF SYNTHESIS | Mitsui Chemicals, Inc. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040030144-A1 | Optically active amine derivative and method of synthesis | ALDH7A1, AADAT, KMO | MAPT 3116/4885ALDH1A1 84/4885MEN1 1560/4885 |
| US-20030199690-A1 | Process for synthesis of D1 receptor antagonists | OPRL1, AVPR1A, AVPR1B | MAPT 4019/4885ALDH1A1 359/4885MEN1 1755/4885 |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | MAPT 2958/4885ALDH1A1 1610/4885MEN1 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.