Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370492 | 0.71 | ALDH1A1 (0.46) | ALDH1A1GAATSHRNPC1RAB9A | |
| SCHEMBL3365060 | 0.68 | LTA4H (0.51) | EPHX2 | |
| SCHEMBL726240 | 0.68 | KDM1A (0.43) | ALDH1A1SLC6A4SLC6A3SLC22A1SLC6A2 | |
| SCHEMBL28829904 | 0.67 | GLA (0.50) | — | |
| SCHEMBL6628369 | 0.67 | LTA4H (0.54) | NPC1RAB9ASMN1; SMN2EPHX2 | |
| SCHEMBL10781112 | 0.66 | SLC6A4 (0.43) | SLC6A4SLC22A1SLC6A2OPRM1CHRM2 | |
| SCHEMBL23835985 | 0.65 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL3718795 | 0.65 | SLC6A2 (0.48) | GAATSHRSLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3367622 | 0.65 | LTA4H (0.48) | — | |
| SCHEMBL13610572 | 0.64 | TSHR (0.52) | ALDH1A1TSHRSLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112876369-A | Synthesis method of venlafaxine hydrochloride intermediate | 北京福元医药股份有限公司沧州分公司 | 2021-06-01 | — | — | CN | disclosed |
| CN-106866434-B | A kind of preparation method of VENLAFAXINE HCL intermediate | 齐鲁天和惠世制药有限公司 | 2018-10-30 | — | — | CN | disclosed |
| CN-104326927-A | Preparation method of 1-[2-amino-1-(4-methoxyphenyl)ethyl]cyclohexanol sulfate | QILU TIANHE PHARMACEUTICAL CO LTD | 2015-02-04 | — | — | CN | disclosed |
| CN-101503365-B | Preparation of venlafaxine intermediate 1-[2-amino-1-(4-methoxy phenyl)ethyl] cyclohexanol | CHENGDU QIAOFENG TECHNOLOGICAL DEV CO LTD | 2012-11-07 | — | — | CN | disclosed |
| US-8304578-B2 | Process for producing 1-[2-(dimethylamino)-1-(4-phenol)ethyl]cyclohexanol | MATRIX LABORATORIES LIMITED (IN) | 2012-11-06 | — | — | US | disclosed |
| US-20100286447-A1 | PROCESS FOR PRODUCING 1-[2-(DIMETHYLAMINO)-1-(4-PHENOL)ETHYL]CYCLOHEXANOL | MATRIX LABORATORIES LIMITED (IN) | 2010-11-11 | — | — | US | disclosed |
| CN-101503365-A | Preparation of venlafaxine intermediate 1-[2-amino-1-(4-methoxy phenyl)ethyl] cyclohexanol | CHENGDU QIAOFENG TECHNOLOGICAL (CN) | 2009-08-12 | — | — | CN | disclosed |
| WO-2009084039-A2 | PROCESS FOR PRODUCING 1-[2-(DIMETHYLAMINO)-1-(4-PHENOL)ETHYL]CYCLOHEXANOL | MATRIX LABORATORIES LIMITED (IN) | 2009-07-09 | — | — | WO | disclosed |
| WO-2007094008-A3 | A NOVEL PROCESS FOR PREPARATION OF VENLAFAXINE HYDROCHLORIDE AND ITS INTERMEDIATES | UNICHEM LAB LTD (IN) | 2009-05-14 | — | — | WO | disclosed |
| WO-2007094008-A2 | A NOVEL PROCESS FOR PREPARATION OF VENLAFAXINE HYDROCHLORIDE AND ITS INTERMEDIATES | UNICHEM LABORATORIES LIMITED (IN) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007094008-A2 | A NOVEL PROCESS FOR PREPARATION OF VENLAFAXINE HYDROCHLORIDE AND ITS INTERMEDIATES | UNICHEM LABORATORIES LIMITED (IN) | 2007-08-23 | — | — | WO | disclosed |
| EP-1238967-B1 | A process for the preparation of 1-(cyano(aryl)methyl) cyclohexanol | COUNCIL SCIENT IND RES (IN) | 2005-04-27 | — | — | EP | disclosed |
| US-6504044-B2 | Reacting cyclohexanone with the carbanions of an aryl acetonitrile using a base, isolating and purifying 1-(cyano(aryl)methyl) cyclohexanol compound by crystallization | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-01-07 | — | — | US | disclosed |
| EP-1238967-A1 | A process for the preparation of 1-(cyano(aryl)methyl) cyclohexanol | Council of Scientific and Industrial Research (IN) | 2002-09-11 | — | — | EP | disclosed |
| US-20020120164-A1 | Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2002-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286447-A1 | PROCESS FOR PRODUCING 1-[2-(DIMETHYLAMINO)-1-(4-PHENOL)ETHYL]CYCLOHEXANOL | COMT, HTR1A, TPH1 | ALDH1A1 358/4885TRPA1 3965/4885GAA 418/4885 |
| US-20020120164-A1 | Process for the preparation of 1-[cyano(aryl)methyl] cyclohexanol | CYP2S1, C1S, CYP1B1 | ALDH1A1 1390/4885TRPA1 4163/4885GAA 2358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.