Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2848852 | 0.84 | GAA (0.45) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL10949613 | 0.82 | HTR2A (0.46) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL6777378 | 0.80 | TUBB4A (0.45) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL6776267 | 0.80 | ALDH1A1 (0.42) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL23888219 | 0.80 | ALDH1A1 (0.42) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL4406929 | 0.78 | HTR2A (0.44) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL17142269 | 0.78 | MAPT (0.44) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL6736267 | 0.78 | HTR2A (0.44) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL27285656 | 0.78 | MAPT (0.44) | GAANPC1HTR2AHTR2CHTR2B | |
| SCHEMBL30715275 | 0.78 | ALDH1A1 (0.46) | GAANPC1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341344-B | Preparation method of kinase inhibitor intermediate | 上海喀露蓝科技有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-112341344-A | Preparation method of kinase inhibitor intermediate | 上海喀露蓝科技有限公司 | 2021-02-09 | — | — | CN | disclosed |
| EP-2755944-B1 | BIARYLDERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI SA (FR) | 2017-06-14 | — | — | EP | disclosed |
| EP-2755944-B1 | BIARYLDERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI SA (FR) | 2017-06-14 | — | — | EP | disclosed |
| US-9624159-B2 | Aniline derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2017-04-18 | — | — | US | disclosed |
| US-9624159-B2 | Aniline derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2017-04-18 | — | — | US | disclosed |
| US-9624159-B2 | Aniline derivatives, their preparation and their therapeutic application | SANOFI (FR) | 2017-04-18 | — | — | US | disclosed |
| US-20160199330-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2016-07-14 | — | — | US | disclosed |
| US-20160199330-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2016-07-14 | — | — | US | disclosed |
| US-20160199330-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2016-07-14 | — | — | US | disclosed |
| WO-2010049302-A1 | NOVEL PHENYL AMIDE OR PYRIDIL AMIDE DERIVATIVES AND THEIR USE AS GPBAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-06 | — | — | WO | disclosed |
| US-20100105906-A1 | NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2010-04-29 | — | — | US | disclosed |
| US-20090137804-A1 | Compounds and Compositions as Protein Kinase Inhibitors | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2009-05-28 | — | — | US | disclosed |
| CN-101035769-A | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG (CH) | 2007-09-12 | — | — | CN | disclosed |
| EP-1761505-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | Novartis AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006000420-A1 | PYRIMIDINE UREA DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-01-05 | — | — | WO | disclosed |
| EP-0377896-A2 | Cyclooxygenase and 5-lipoxygenase inhibiting hydroxamic acid derivatives | CIBA-GEIGY AG (CH) | 1990-07-18 | — | — | EP | disclosed |
| EP-0048363-B1 | IMIDAZOLE DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND DRUGS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-07-31 | — | — | EP | disclosed |
| US-4366160-A | ANALGESICS | HOFFMANN-LA ROCHE INC. (US) | 1982-12-28 | — | — | US | disclosed |
| EP-0048363-A2 | Imidazole derivatives, processes and intermediates for their preparation and drugs containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137804-A1 | Compounds and Compositions as Protein Kinase Inhibitors | MAP3K20, MAP3K1, CDK1 | GAA 1213/4885NPC1 2089/4885HTR2A 4355/4885 |
| US-20160199330-A1 | ANILINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | CYP11B1, ARG2, CYP11B2 | GAA 2628/4885NPC1 666/4885HTR2A 862/4885 |
| US-20100105906-A1 | NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES | GPBAR1, GPR119, GLP1R | GAA 1013/4885NPC1 504/4885HTR2A 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.