SCHEMBL374366

SCHEMBL374366

NC(=O)Oc1ccc(F)cc1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.55
KMT2A Q03164 3/20 0.52
MEN1 O00255 1/20 0.52
MAOB P27338 1/20 0.46
PARP10 Q53GL7 1/20 0.46
ALDH1A1 P00352 2/20 0.45
KCNN4 O15554 1/20 0.45
ATM Q13315 1/20 0.44
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
SCN4A P35499 1/20 0.42
SCN9A Q15858 1/20 0.42
SOS1 Q07889 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31109007 0.94 KIF11 (0.65) KIF11KMT2AMEN1MAOBPARP10
SCHEMBL4246486 0.88 KMT2A (0.55) KIF11KMT2AMEN1MAOBPARP10
SCHEMBL6284986 0.87 KMT2A (0.64) KIF11KMT2AMEN1PARP10ALDH1A1
SCHEMBL21551494 0.82 MAOB (0.43) KIF11KMT2AMAOBPARP10ALDH1A1
SCHEMBL28783426 0.81 KMT2A (0.53) KIF11KMT2AMEN1MAOBPARP10
Guanidine SCHEMBL27421363 0.80 KMT2A (0.45) KIF11KMT2AMEN1MAOBPARP10
SCHEMBL57245 0.80 KMT2A (0.50) KMT2AMEN1ALDH1A1ATMCES2
SCHEMBL3741169 0.79 KMT2A (0.54) KIF11KMT2AMEN1MAOBPARP10
Guanidine SCHEMBL6814628 0.79 KMT2A (0.44) KMT2AMAOBPARP10ALDH1A1KCNN4
SCHEMBL14389790 0.78 KMT2A (0.46) KMT2AALDH1A1ATMCES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 599 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240299568-A1 BONE-SPECIFIC DELIVERY OF POLYPEPTIDES WILLIAM MARSH RICE UNIVERSITY (US) 2024-09-12 US claimed
CN-117529338-A Bone-specific delivery of polypeptides 威廉马歇莱思大学 2024-02-06 CN claimed
EP-4281116-A1 BONE-SPECIFIC DELIVERY OF POLYPEPTIDES William Marsh Rice University (US) 2023-11-29 EP claimed
CN-114957112-B (2-chloroquinoline-3-yl) methyl (N-p-fluorophenyl) carbamate and preparation method and application thereof 渤海大学 2023-01-17 CN claimed
CN-114957112-A (2-chloroquinoline-3-yl) methyl (N-p-fluorophenyl) carbamate and preparation method and application thereof 渤海大学 2022-08-30 CN claimed
WO-2022159492-A1 BONE-SPECIFIC DELIVERY OF POLYPEPTIDES WILLIAM MARSH RICE UNIVERSITY (US) 2022-07-28 WO claimed
CN-113214339-A Panaxadiol derivatives, preparation method and medical application thereof 延边大学 2021-08-06 CN claimed
US-11076600-B2 Mixtures of cis-jasmone and bacillus amyloliquefaciens BASF SE (DE) 2021-08-03 US claimed
CN-106831792-B A kind of preparation method of PARP inhibitor Rucaparib intermediate 李绵利 2019-02-12 CN claimed
US-20180360041-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors BASF SE (DE) 2018-12-20 US claimed
CN-101257798-A Fungicidal mixtures comprising substituted 1-methylpyrazol-4-ylcarboxanilides BASF SE (DE) 2008-09-03 CN claimed
CN-101247723-A Fungicide mixtures based on 3-monosubstituted pyrazole carboxylic acid biphenyl amides BASF SE (DE) 2008-08-20 CN claimed
CN-101217873-A Fungicidal mixtures made from 1-methylpyrazol-4-ylcarboxanilides BASF AG (DE) 2008-07-09 CN claimed
CN-101212900-A Fungicide mixtures based on 2,4-disubstituted pyrazole carboxylic acid biphenylamides BASF AG (DE) 2008-07-02 CN claimed
CN-101212902-A Fungicidal mixtures based on 3, 5-disubstituted pyrazole carboxylic acid biphenylamides BASF AG (DE) 2008-07-02 CN claimed
CN-101212901-A Fungicidal mixtures based on 2,5-disubstituted pyrazol carboxylic acid biphenylamides BASF AG (DE) 2008-07-02 CN claimed
CN-101166733-A Pyrazole derivatives as phosphodiesterase 4 inhibitors MEMORY PHARM CORP (US) 2008-04-23 CN claimed
EP-1904446-A2 AZABICYCLO DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS Ranbaxy Laboratories Limited (IN) 2008-04-02 EP claimed
WO-2007007282-A2 AZABICYCLO DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2007-01-18 WO claimed
CN-1826324-A Indazole, benzisoxazole and benzisothiazole kinase inhibitors ABBOTT LAB (US) 2006-08-30 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11076600-B2 Mixtures of cis-jasmone and bacillus amyloliquefaciens BAX, FASN, BAK1 KIF11 4675/4885KMT2A 4623/4885MEN1 481/4885
US-20180360041-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors SQOR, COX5B, UQCRB KIF11 3125/4885KMT2A 3197/4885MEN1 2720/4885
US-20240299568-A1 BONE-SPECIFIC DELIVERY OF POLYPEPTIDES SOST, BST2, ACP3 KIF11 1287/4885KMT2A 3635/4885MEN1 363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.