Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3752822 | 0.92 | AVPR1B (0.52) | HTR6KCNH2AVPR1BACLYPKM | |
| Trifluoroacetic Acid SCHEMBL3755402 | 0.92 | AVPR1B (0.53) | HTR6KCNH2AVPR1BPKMTPSAB1 | |
| Trifluoroacetic Acid SCHEMBL3752797 | 0.92 | AVPR1B (0.52) | HTR6KCNH2AVPR1BPKMTPSAB1 | |
| SCHEMBL3750899 | 0.82 | ACLY (0.46) | HTR6AVPR1BACLYBACE1 | |
| SCHEMBL3751705 | 0.82 | HTR6 (0.56) | HTR6KCNH2AVPR1B | |
| Trifluoroacetic Acid SCHEMBL3752788 | 0.80 | AVPR1B (0.54) | HTR6KCNH2AVPR1BOXTR | |
| Trifluoroacetic Acid SCHEMBL3749338 | 0.77 | AVPR1B (0.63) | HTR6KCNH2AVPR1BPKMOXTR | |
| SCHEMBL3759249 | 0.75 | ALDH1A1 (0.45) | HTR6AVPR1BACLY | |
| SCHEMBL3754777 | 0.74 | ALDH1A1 (0.48) | HTR6AVPR1BACLY | |
| SCHEMBL3747271 | 0.74 | ALDH1A1 (0.46) | HTR6AVPR1BACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838518-B2 | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders | N.V. ORGANON (NL) | 2010-11-23 | — | — | US | disclosed |
| EP-1476151-B1 | 1-ARYLSULFONYL-3-SUBSTITUED INDOLE AND INDOLINE DERIVATES USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORGANON NV (NL) | 2008-07-16 | — | — | EP | disclosed |
| US-20050154023-A1 | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders | MERCK SHARP & DOHME B.V. (NL) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154023-A1 | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders | TPH1, HTR1A, HTR1D | HTR6 12/4885KCNH2 718/4885AVPR1B 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.