Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UPP1 | Q16831 | 1/20 | 0.72 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800214 | 1.00 | UPP1 (0.72) | UPP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL37456 | 1.00 | UPP1 (0.72) | UPP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL13376174 | 1.00 | UPP1 (0.72) | UPP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL2671532 | 0.89 | UPP1 (0.74) | UPP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL4982268 | 0.89 | UPP1 (0.74) | UPP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL11648434 | 0.89 | UPP1 (0.58) | UPP1ALDH1A1CYP2C19HPGDMAPT | |
| SCHEMBL2672608 | 0.89 | UPP1 (0.74) | UPP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL11648441 | 0.89 | UPP1 (0.58) | UPP1ALDH1A1CYP2C19HPGDMAPT | |
| SCHEMBL8053414 | 0.89 | UPP1 (0.74) | UPP1CHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL16749118 | 0.89 | UPP1 (0.58) | UPP1ALDH1A1CYP2C19HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2341772-B1 | SYNTHESIS OF DECITABINE | SCINOPHARM TAIWAN LTD (TW) | 2013-04-17 | — | — | EP | claimed |
| EP-2467391-B1 | PROCESS FOR THE PREPARATION OF CLADRIBINE | SCINOPHARM KUNSHAN BIOCHEMICAL TECHNOLOGY CO LTD (CN) | 2016-04-27 | — | — | EP | disclosed |
| EP-2891660-A1 | Process for the preparation of cladribine | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. (CN) | 2015-07-08 | — | — | EP | disclosed |
| EP-2318423-B1 | PROCESS FOR MAKING 5-AZACYTOSINE NUCLEOSIDES AND THEIR DERIVATIVES | SCINOPHARM TAIWAN LTD (TW) | 2014-05-07 | — | — | EP | disclosed |
| US-8586729-B2 | Synthesis of decitabine | SCINOPHARM TAIWAN LTD. (TW) | 2013-11-19 | — | — | US | disclosed |
| US-8338586-B2 | Process of making cladribine | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2012-12-25 | — | — | US | disclosed |
| US-20120197010-A1 | PROCESS OF MAKING CLADRIBINE | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2012-08-02 | — | — | US | disclosed |
| US-8232387-B2 | Process for the preparation of cladribine | SCINOPHARM TAIWAN, LTD. (TW) | 2012-07-31 | — | — | US | disclosed |
| EP-2467391-A1 | PROCESS FOR THE PREPARATION OF CLADRIBINE | Scinopharm (Kunshan) Biochemical Technology Co., Ltd. (CN) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011020298-A1 | PROCESS FOR THE PREPARATION OF CLADRIBINE | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2011-02-24 | — | — | WO | disclosed |
| US-20110046363-A1 | Process for the Preparation of Cladribine | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2011-02-24 | — | — | US | disclosed |
| US-20100087637-A1 | Synthesis of Decitabine | SCINOPHARM TAIWAN LTD. | 2010-04-08 | — | — | US | disclosed |
| US-20100036112-A1 | Process for Making 5-Azacytosine Nucleosides and Their Derivatives | SCINOPHARM TAIWAN LTD. | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100036112-A1 | Process for Making 5-Azacytosine Nucleosides and Their Derivatives | DCTD, DUT, DPYD | UPP1 76/4885CHRNB2 4868/4885CHRNA5 3798/4885 |
| US-20100087637-A1 | Synthesis of Decitabine | DCTD, DUT, DPYD | UPP1 87/4885CHRNB2 3996/4885CHRNA5 3324/4885 |
| US-20120197010-A1 | PROCESS OF MAKING CLADRIBINE | PNP, CPSF1, NSUN2 | UPP1 26/4885CHRNB2 4322/4885CHRNA5 4187/4885 |
| US-20110046363-A1 | Process for the Preparation of Cladribine | ADAR, RNMT, RNGTT | UPP1 300/4885CHRNB2 3456/4885CHRNA5 3098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.