SCHEMBL3747872

SCHEMBL3747872

C=C(C[Si](C)(C)Cl)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.48
MAOB P27338 6/20 0.48
CES2 O00748 2/20 0.36
CES1 P23141 2/20 0.36
EGFR P00533 1/20 0.35
ALDH1A1 P00352 2/20 0.34
TRPA1 O75762 1/20 0.34
MAPK1 P28482 1/20 0.34
GSK3B P49841 1/20 0.34
HIF1A Q16665 1/20 0.34
MAPT P10636 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3183060 0.83 MAOA (0.52) MAOAMAOBCES1ALDH1A1TRPA1
SCHEMBL5995457 0.83 MAOA (0.47) MAOAMAOBEGFRALDH1A1MAPT
SCHEMBL184898 0.76 MAOA (0.46) MAOAMAOBEGFRALDH1A1MAPK1
SCHEMBL8189072 0.75 MAOA (0.48) MAOAMAOBCES2CES1EGFR
SCHEMBL11654664 0.71 MAOA (0.39) MAOAMAOBCES2CES1EGFR
SCHEMBL8383505 0.71 MAOA (0.44) MAOAMAOBEGFRALDH1A1MAPK1
SCHEMBL15851 0.70 ALDH1A1 (0.52) MAOAMAOBCES1ALDH1A1TRPA1
SCHEMBL14958 0.70 MAOA (0.52) MAOAMAOBCES2CES1EGFR
SCHEMBL19409831 0.70 MAOA (0.47) MAOAMAOBCES2CES1EGFR
SCHEMBL17894174 0.69 MAOA (0.50) MAOAMAOBEGFRALDH1A1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8835561-B2 Rubber composition containing branched blocked polymers MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2014-09-16 US claimed
EP-1915408-B1 RUBBER COMPOSITION CONTAINING BRANCHED BLOCK POLYMERS MICHELIN & CIE (FR) 2013-10-02 EP claimed
US-20100154945-A1 Rubber composition containing branched blocked polymers MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2010-06-24 US claimed
EP-1915408-A1 RUBBER COMPOSITION CONTAINING BRANCHED BLOCK POLYMERS Societe de Technologie Michelin (FR) 2008-04-30 EP claimed
WO-2007014998-A1 RUBBER COMPOSITION CONTAINING BRANCHED BLOCK POLYMERS SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2007-02-08 WO claimed
US-8835561-B2 Rubber composition containing branched blocked polymers MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2014-09-16 US disclosed
EP-1915408-B1 RUBBER COMPOSITION CONTAINING BRANCHED BLOCK POLYMERS MICHELIN & CIE (FR) 2013-10-02 EP disclosed
US-20100154945-A1 Rubber composition containing branched blocked polymers MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) 2010-06-24 US disclosed
EP-1915408-A1 RUBBER COMPOSITION CONTAINING BRANCHED BLOCK POLYMERS Societe de Technologie Michelin (FR) 2008-04-30 EP disclosed
WO-2007014998-A1 RUBBER COMPOSITION CONTAINING BRANCHED BLOCK POLYMERS SOCIETE DE TECHNOLOGIE MICHELIN (FR) 2007-02-08 WO disclosed