SCHEMBL374875

SCHEMBL374875

COc1ccc(C=C(C(=O)OCC(C)(C)C)C(=O)OCC(C)(C)C)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.48
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
NPSR1 Q6W5P4 3/20 0.48
LMNA P02545 2/20 0.48
CYP1A2 P05177 2/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
S1PR4 O95977 1/20 0.48
S1PR1 P21453 1/20 0.48
MAPK1 P28482 1/20 0.48
NR1H4 Q96RI1 1/20 0.46
GSK3B P49841 1/20 0.44
KDM4E B2RXH2 2/20 0.44
ALDH1A1 P00352 2/20 0.44
HPGD P15428 2/20 0.44
F3 P13726 1/20 0.42
CYP3A4 P08684 1/20 0.41
TSHR P16473 1/20 0.41
NFKB1 P19838 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16166799 0.93 KMT2A (0.44) MAPTMEN1KMT2ANPSR1LMNA
SCHEMBL10921481 0.92 MAPT (0.42) MAPTMEN1KMT2ANPSR1LMNA
SCHEMBL14273870 0.84 ALDH1A1 (0.51) MAPTMEN1KMT2ANPSR1LMNA
SCHEMBL12663178 0.84 KMT2A (0.67) MAPTMEN1KMT2ANPSR1LMNA
SCHEMBL4004260 0.83 MEN1 (0.49) MAPTMEN1KMT2ANPSR1LMNA
SCHEMBL438314 0.83 MEN1 (0.70) MAPTMEN1KMT2ANPSR1LMNA
SCHEMBL4963610 0.82 NR1H4 (0.47) MAPTMEN1KMT2ANPSR1LMNA
SCHEMBL3717127 0.80 ALDH1A1 (0.47) MAPTNPSR1CYP1A2GSK3BKDM4E
SCHEMBL934462 0.79 MAPT (0.62) MAPTMEN1KMT2ANPSR1LMNA
SCHEMBL21121046 0.79 NR1H4 (0.46) MAPTMEN1KMT2ANPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 398 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4391993-A1 W/O TYPE COMPOSITION COMPRISING ORGANIC UV FILTER AND SPHERICAL HYDROPHOBIC SILICA L'OREAL (FR) 2024-07-03 EP claimed
WO-2023026893-A1 W/O TYPE COMPOSITION COMPRISING ORGANIC UV FILTER AND SPHERICAL HYDROPHOBIC SILICA L'OREAL (FR) 2023-03-02 WO claimed
US-20200261748-A1 PHOTOPROTECTIVE COMPOSITIONS COMPRISING AN AQUEOUS PHASE AND A LOW MELTING POINT APOLAR WAX L'OREAL (FR) 2020-08-20 US claimed
EP-2485708-B1 PHOTOPROTECTIVE COMPOSITION BASED ON A 2-ALKOXY-4-ALKYL KETONE PHENOL COMPOUND; USE OF SAID COMPOUND FOR INCREASING THE SUN PROTECTION FACTOR OREAL (FR) 2018-08-22 EP claimed
WO-2018012557-A1 W/O SUN CARE COMPOSITION INCLUDING POROUS ORGANIC PARTICLE L'OREAL (FR) 2018-01-18 WO claimed
US-20170135933-A1 PHOTOPROTECTIVE COMPOSITIONS COMPRISING PHOTOSENSITIVE 1,3,5-TRIAZINE COMPOUNDS, DIBENZOYLMETHANE COMPOUNDS AND SILICEOUS S-TRIAZINES SUBSTITUTED WITH TWO AMINOBENZOATE OR AMINOBENZAMIDE GROUPS L'OREAL (FR) 2017-05-18 US claimed
US-9526924-B2 Composition comprising a screening agent of the lipophilic 2-hydroxybenzophenone type and a silicon-compromising s-triazine substituted by at least two alkylaminobenzoate groups L'OREAL (FR) 2016-12-27 US claimed
EP-2470158-B1 COMPOSITION CONTAINING AT LEAST ONE LIPOPHILIC 2-HYDROXYBENZOPHENONE FILTER AND A SILICON S-TRIAZINE SUBSTITUTED BY AT LEAST TWO ALKYLAMINOBENZOATE GROUPS ORÉAL L (FR) 2016-10-05 EP claimed
US-8961941-B2 Composition comprising a dibenzoylmethane screening agent and a merocyanine dicyano or cyanoacetate derivative; method for the photostabilization of the dibenzoylmethane screening agent L'OREAL (FR) 2015-02-24 US claimed
US-8778313-B2 Aqueous fluid photoprotective compositions comprising ester-terminated poly(ester amide) polymers L'OREAL (FR) 2014-07-15 US claimed
US-7402300-B2 Sunscreen compositions comprising lipophilic UV-screening agents and hydroxyalkylurea compounds L'OREAL (FR) 2008-07-22 US claimed
US-20080145324-A1 UV-photoprotective compositions comprising diebenzoylmethane screening agents and silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups L'OREAL (FR) 2008-06-19 US claimed
US-20080138303-A1 Photoprotective cosmetic compositions comprising silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups and non-silicon-containing lipophilic triazine compound UV-screening agents L'OREAL (FR) 2008-06-12 US claimed
US-20080115846-A1 Aqueous fluid photoprotective compositions comprising ester-terminated poly(ester amide) polymers L'OREAL (FR) 2008-05-22 US claimed
US-20080044365-A1 Concave or annular particles of silicone materials for increasing the sun protection factor of aqueous photoprotective compositions comprising same L'OREAL (FR) 2008-02-21 US claimed
US-20080019930-A1 Dibenzoylmethane sunscreens photostabilized with arylalkyl amide or ester compounds L'OREAL (FR) 2008-01-24 US claimed
WO-2007080053-A2 COSMETIC COMPOSITION CONTAINING A DIBENZOYLMETHANE DERIVATIVE AND A PHENOL OR BISPHENOL COMPOUND; PROCESS FOR PHOTOSTABILIZATION OF THE DIBENZOYLMETHANE DERIVATIVE L'ORÉAL (FR) 2007-07-19 WO claimed
WO-2007080052-A1 COSMECTIC COMPOSITION CONTAINING A DIBENZOYLMETHANE DERIVATIVE AND A SILOXANE-CONTAINING PHENOL OR BISPHENOL COMPOUND; PROCESS FOR PHOTOSTABILIZATION OF THE DIBENZOYLMETHANE DERIVATIVE L'ORÉAL (FR) 2007-07-19 WO claimed
US-20070009453-A1 Photoprotective compositions comprising an aqueous phase and a low melting point apolar wax L'OREAL (FR) 2007-01-11 US claimed
US-20060177393-A1 Sunscreen compositions comprising lipophilic UV-screening agents and hydroxyalkylurea compounds L'OREAL (FR) 2006-08-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060177393-A1 Sunscreen compositions comprising lipophilic UV-screening agents and hydroxyalkylurea compounds CUTA, S100A11, KRT18 MAPT 2165/4885MEN1 3409/4885KMT2A 2745/4885
US-20080145324-A1 UV-photoprotective compositions comprising diebenzoylmethane screening agents and silicon-containing s-triazine compounds substituted with two aminobenzoate or aminobenzamide groups TST, TYR, DDT MAPT 455/4885MEN1 3080/4885KMT2A 672/4885
US-20080019930-A1 Dibenzoylmethane sunscreens photostabilized with arylalkyl amide or ester compounds TYR, DDT, AADAC MAPT 688/4885MEN1 3267/4885KMT2A 1285/4885
US-20080044365-A1 Concave or annular particles of silicone materials for increasing the sun protection factor of aqueous photoprotective compositions comprising same ERCC4, BRCA1, ERCC2 MAPT 3451/4885MEN1 2410/4885KMT2A 3838/4885
US-20170135933-A1 PHOTOPROTECTIVE COMPOSITIONS COMPRISING PHOTOSENSITIVE 1,3,5-TRIAZINE COMPOUNDS, DIBENZOYLMETHANE COMPOUNDS AND SILICEOUS S-TRIAZINES SUBSTITUTED WITH TWO AMINOBENZOATE OR AMINOBENZAMIDE GROUPS CUTA, TST, DSG1 MAPT 36/4885MEN1 1269/4885KMT2A 731/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.