Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALPG | P10696 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1435655 | 1.00 | ALDH1A1 (0.59) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| SCHEMBL25664229 | 0.98 | ALDH1A1 (0.61) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| SCHEMBL7050647 | 0.98 | ALDH1A1 (0.61) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| SCHEMBL1405466 | 0.82 | ALDH1A1 (0.81) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| SCHEMBL3217836 | 0.82 | ALDH1A1 (0.81) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| SCHEMBL3217829 | 0.82 | ALDH1A1 (0.81) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| SCHEMBL3217840 | 0.82 | ALDH1A1 (0.81) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| SCHEMBL1405467 | 0.82 | ALDH1A1 (0.81) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| Hydrochloric Acid SCHEMBL3748847 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPK1HSD17B10TSHRTDP1 | |
| SCHEMBL1435234 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPK1HSD17B10TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844109-B1 | USE OF CATIONIC AZACYANINE DYES FOR COLORING KERATIN FIBERS | PROCTER & GAMBLE (US) | 2011-03-30 | — | — | EP | disclosed |
| US-7517367-B2 | Cationic naphthyldiazo dyes and keratin fibers-coloring agents containing these dyes | WELLA AG (DE) | 2009-04-14 | — | — | US | disclosed |
| US-7455698-B2 | Cationic dyes and dyestuff for keratin fibres containing said compounds | WELLA AG (DE) | 2008-11-25 | — | — | US | disclosed |
| US-7413578-B2 | Symmetric and assymetric dyes with a mesomeric structure, e.g., 2-[(1-ethyl-4(1H)-quinolinylidene)amino]-6-methoxy-3-methyl-1,3-benzothiazol-3-ium tetrafluoroborate; may be used to dye predamaged sections of hair without oxidizing agent neat or mixed with an acidic, neutral or basic aqueous diluent | THE PROCTER & GAMBLE COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| US-7410507-B2 | Use of cationic azacyanine dyes for coloring keratin fibers | THE PROCTER & GAMBLE COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-20080167453-A1 | Cationic Naphthyldiazo Dyes and Keratin Fibers-Coloring Agents Containing These Dyes | WELLA AG (DE) | 2008-07-10 | — | — | US | disclosed |
| US-20070258929-A1 | Cationic Dyes and Dyestuff for Keratin Fibres Containing Said Compounds | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2007-11-08 | — | — | US | disclosed |
| US-20070022545-A1 | Use of cationic azacyanine dyes for coloring keratin fibers | PROCTER & GAMBLE COMPANY, THE | 2007-02-01 | — | — | US | disclosed |
| US-20070000071-A1 | Colorants comprising cationic azacyanine dyes | PROCTER & GAMBLE COMPANY, THE | 2007-01-04 | — | — | US | disclosed |
| US-20040034945-A1 | Lightening dye with direct-dyeing colorants | WELLA AKTIENGESELLSCHAFT (DE) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167453-A1 | Cationic Naphthyldiazo Dyes and Keratin Fibers-Coloring Agents Containing These Dyes | KRT18, KPNB1, KPNA3 | ALDH1A1 1280/4885MAPK1 935/4885HSD17B10 3536/4885 |
| US-20070022545-A1 | Use of cationic azacyanine dyes for coloring keratin fibers | KRT18, AZI2, MKI67 | ALDH1A1 391/4885MAPK1 882/4885HSD17B10 1928/4885 |
| US-20070258929-A1 | Cationic Dyes and Dyestuff for Keratin Fibres Containing Said Compounds | KRT18, IK, S100A4 | ALDH1A1 666/4885MAPK1 1178/4885HSD17B10 2135/4885 |
| US-20040034945-A1 | Lightening dye with direct-dyeing colorants | KRT18, TUBB1, TUBA1C | ALDH1A1 37/4885MAPK1 207/4885HSD17B10 991/4885 |
| US-20070000071-A1 | Colorants comprising cationic azacyanine dyes | KRT18, IK, NUP205 | ALDH1A1 1520/4885MAPK1 1181/4885HSD17B10 3791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.