Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16958899 | 0.87 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CHRM1ALOX15MAOA | |
| SCHEMBL11185624 | 0.87 | PTPN1 (0.50) | ALDH1A1CYP3A4CHRM1ALOX15MAOA | |
| SCHEMBL18523730 | 0.85 | ALDH1A1 (0.43) | ALDH1A1CYP3A4CHRM1ALOX15MAOA | |
| SCHEMBL1133298 | 0.85 | ALDH1A1 (0.45) | ALDH1A1CYP3A4FFAR4POLBCYP1A2 | |
| SCHEMBL16009653 | 0.84 | ALDH1A1 (0.44) | ALDH1A1CYP3A4FFAR4POLBCYP1A2 | |
| SCHEMBL16134065 | 0.84 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CHRM1ALOX15MAOA | |
| SCHEMBL7627906 | 0.80 | ALDH1A1 (0.40) | ALDH1A1CYP3A4MCL1FFAR4TSHR | |
| SCHEMBL17522141 | 0.80 | FKBP1A (0.45) | ALDH1A1CYP3A4FFAR4TSHRPOLB | |
| SCHEMBL11177610 | 0.79 | KDM4E (0.42) | ALDH1A1CYP3A4CHRM1ALOX15MAOA | |
| SCHEMBL9847949 | 0.77 | ALDH1A1 (0.46) | ALDH1A1CYP3A4FFAR4TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104327106-A | Preparation method of high-sterically-hindered arylborate compound | SHENZHEN RES INST THE HONG KONG POLYTECHNIC UNIVERSITY | 2015-02-04 | — | — | CN | claimed |
| US-20220396549-A1 | SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF | UNIV MARYLAND (US) | 2022-12-15 | — | — | US | disclosed |
| WO-2022253713-A1 | TARGETED PROTEIN DEGRADATION USING BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2022-12-08 | — | — | WO | disclosed |
| EP-3319938-B1 | SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF | UNIV MARYLAND (US) | 2022-04-06 | — | — | EP | disclosed |
| US-10858316-B2 | Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2020-12-08 | — | — | US | disclosed |
| US-20180208554-A1 | Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof | UNIVERSITY OF MARYLAND, BALTIMORE | 2018-07-26 | — | — | US | disclosed |
| US-20180208554-A1 | Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof | UNIVERSITY OF MARYLAND, BALTIMORE | 2018-07-26 | — | — | US | disclosed |
| WO-2017011323-A1 | SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-01-19 | — | — | WO | disclosed |
| US-20160194279-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-07 | — | — | US | disclosed |
| US-20160194279-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-07 | — | — | US | disclosed |
| US-20100304966-A1 | Fungicidal Compounds, Method For the Production Thereof, And Use Thereof To Combat Damaging Fungi, And Agents Comprising The Same | BASF SE (DE) | 2010-12-02 | — | — | US | disclosed |
| US-7161022-B2 | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative | FUJIFILM FINECHEMICALS CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| US-7161022-B2 | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative | FUJIFILM FINECHEMICALS CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| US-20050250846-A1 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | ANDERSON MARK B | 2005-11-10 | — | — | US | disclosed |
| EP-1560818-A1 | NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE | PFIZER INC. (US) | 2005-08-10 | — | — | EP | disclosed |
| US-6903132-B2 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-06-07 | — | — | US | disclosed |
| US-20040014787-A1 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003106446-A1 | NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE | PFIZER INC. (US) | 2003-12-24 | — | — | WO | disclosed |
| EP-0088346-B1 | 2-AMINOMETHYL-PHENOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-06-05 | — | — | EP | disclosed |
| EP-0088346-A2 | 2-Aminomethyl-phenol derivatives, process for their preparation, their use and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250846-A1 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | GNRHR, LHCGR, FSHR | ALDH1A1 4773/4885CYP3A4 2533/4885CHRM1 4636/4885 |
| US-20220396549-A1 | SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEROF | MCL1, TP53, MYC | ALDH1A1 2903/4885CYP3A4 4789/4885CHRM1 4880/4885 |
| US-20040014787-A1 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | GNRHR, LHCGR, FSHR | ALDH1A1 4773/4885CYP3A4 2533/4885CHRM1 4636/4885 |
| US-10858316-B2 | Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof | MCL1, BCL3, BCL9 | ALDH1A1 2863/4885CYP3A4 4773/4885CHRM1 4881/4885 |
| US-20180208554-A1 | Small Molecule Inhibitors of the MCL-1 Oncoprotein and Uses Thereof | MCL1, BCL3, BCL9 | ALDH1A1 2863/4885CYP3A4 4773/4885CHRM1 4881/4885 |
| US-20160194279-A1 | ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS | TRRAP, NAT1, AHR | ALDH1A1 445/4885CYP3A4 167/4885CHRM1 3479/4885 |
| US-20100304966-A1 | Fungicidal Compounds, Method For the Production Thereof, And Use Thereof To Combat Damaging Fungi, And Agents Comprising The Same | CYP51A1, ERG28, CAT | ALDH1A1 651/4885CYP3A4 55/4885CHRM1 4151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.