Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.41 |
| ▸ | POLA1 | P09884 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411510 | 1.00 | ESR1 (0.49) | ESR1ESR2ALDH1A1LMNACYP3A4 | |
| SCHEMBL3427486 | 0.91 | ALDH1A1 (0.45) | ESR1ESR2ALDH1A1LMNACYP3A4 | |
| SCHEMBL3411469 | 0.84 | ALDH1A1 (0.47) | ESR1ESR2ALDH1A1LMNACYP3A4 | |
| SCHEMBL3408960 | 0.84 | ALDH1A1 (0.47) | ESR1ESR2ALDH1A1LMNACYP3A4 | |
| SCHEMBL3408957 | 0.84 | ALDH1A1 (0.47) | ESR1ESR2ALDH1A1LMNACYP3A4 | |
| SCHEMBL3706515 | 0.81 | DGAT1 (0.45) | ALDH1A1LMNADGAT1 | |
| SCHEMBL8011044 | 0.81 | DGAT1 (0.39) | ALDH1A1DGAT1 | |
| SCHEMBL13899941 | 0.80 | ESR1 (0.54) | ESR1ESR2ALDH1A1LMNACYP3A4 | |
| SCHEMBL3431277 | 0.80 | ESR2 (0.52) | ESR1ESR2ALDH1A1LMNACYP3A4 | |
| SCHEMBL17211804 | 0.80 | DGAT1 (0.60) | ESR1ESR2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450522-B2 | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders | AMGEN INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20100298367-A1 | Conformationally Constrained Carboxylic Acid Derivatives Useful for Treating Metabolic Disorders | AMGEN INC. | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298367-A1 | Conformationally Constrained Carboxylic Acid Derivatives Useful for Treating Metabolic Disorders | PC, GOT2, CS | ESR1 2100/4885ESR2 1600/4885ALDH1A1 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.