SCHEMBL375020

SCHEMBL375020

CC(=O)Nc1cc(F)ccc1Br

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.50
HDAC1 Q13547 4/20 0.47
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA9 Q16790 2/20 0.46
HDAC6 Q9UBN7 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.44
GAA P10253 1/20 0.44
ALDH1A1 P00352 4/20 0.43
POLB P06746 2/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CCNA2 P20248 1/20 0.43
CDK2 P24941 1/20 0.43
CCNA1 P78396 1/20 0.43
HDAC3 O15379 1/20 0.43
HDAC2 Q92769 1/20 0.43
NCOR2 Q9Y618 1/20 0.43
RAB9A P51151 3/20 0.43
DYRK1A Q13627 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30005976 1.00 RXFP1 (0.50) RXFP1HDAC1CA1CA2CA9
SCHEMBL422893 0.85 CA1 (0.58) RXFP1HDAC1CA1CA2CA9
SCHEMBL30559973 0.85 CA1 (0.58) RXFP1HDAC1CA1CA2CA9
SCHEMBL1704181 0.83 ALDH1A1 (0.44) HDAC1HDAC6SMN1; SMN2GAAALDH1A1
SCHEMBL20560249 0.81 ALOX15 (0.43) HDAC1HDAC6SMN1; SMN2GAAALDH1A1
SCHEMBL30748254 0.81 SMN1; SMN2 (0.55) HDAC1CA1CA2CA9HDAC6
SCHEMBL8955980 0.81 SMN1; SMN2 (0.55) HDAC1CA1CA2CA9HDAC6
SCHEMBL3715354 0.81 ALDH1A1 (0.58) RXFP1HDAC1CA1CA2CA9
SCHEMBL28355716 0.81 KMT2A (0.46) SMN1; SMN2GAAALDH1A1POLBMEN1
SCHEMBL1282557 0.81 PDK1 (0.45) CA1CA2CA9GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115305-A1 LINKERS, CONJUGATES AND APPLICATIONS THEREOF GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) 2026-04-30 US disclosed
US-12539336-B2 Antibody, linkers, payload, conjugates and applications thereof GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. (CN) 2026-02-03 US disclosed
US-20250387505-A1 ANTI-FGFR3 ANTIBODY CONJUGATE AND MEDICAL USE THEREOF GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) 2025-12-25 US disclosed
US-20250064953-A1 Antibody, Linkers, Payload, Conjugates and Applications Thereof GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. (CN) 2025-02-27 US disclosed
US-20250064957-A1 EXATECAN DERIVATIVES, LINKER-PAYLOADS, AND CONJUGATES AND THEREOF GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. (CN) 2025-02-27 US disclosed
EP-4480957-A2 EXATECAN DERIVATIVES, LINKER-PAYLOADS, AND CONJUGATES AND THEREOF Genequantum Healthcare (Suzhou) Co., Ltd. (CN) 2024-12-25 EP disclosed
US-20240327416-A1 Further Substituted Triazolo Quinoxaline Derivatives GRUENENTHAL GMBH (DE) 2024-10-03 US disclosed
EP-4211145-B1 EXATECAN DERIVATIVES, LINKER-PAYLOADS, AND CONJUGATES THEREOF GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) 2024-08-28 EP disclosed
WO-2024002154-A9 ANTI-FGFR3 ANTIBODY CONJUGATE AND MEDICAL USE THEREOF GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. (CN) 2024-07-18 WO disclosed
CN-117279932-B Esatitecan derivatives and linker-carriers and conjugates thereof 启德医药科技(苏州)有限公司 2024-07-05 CN disclosed
US-7517906-B2 Dimeric IAP inhibitors TETRALOGIC PHARMACEUTICALS CORPORATION (US) 2009-04-14 US disclosed
US-7517906-B2 Dimeric IAP inhibitors TETRALOGIC PHARMACEUTICALS CORPORATION (US) 2009-04-14 US disclosed
US-7517906-B2 Dimeric IAP inhibitors TETRALOGIC PHARMACEUTICALS CORPORATION (US) 2009-04-14 US disclosed
CN-101128425-A Dimeric IAP inhibitors TETRALOGIC PHARMACEUTICALS (US) 2008-02-20 CN disclosed
WO-2008014263-A2 DIMERIC IAP ANTAGONISTS TETRALOGIC PHARMACEUTICALS CORPORATION (US) 2008-01-31 WO disclosed
US-20080020986-A1 DIMERIC IAP INHIBITORS TETRALOGIC BIRINAPANT UK LTD (GB) 2008-01-24 US disclosed
US-20080020986-A1 DIMERIC IAP INHIBITORS TETRALOGIC BIRINAPANT UK LTD (GB) 2008-01-24 US disclosed
EP-1851200-A2 DIMERIC IAP INHIBITORS TETRALOGIC PHARMACEUTICALS CORPORATION (US) 2007-11-07 EP disclosed
US-20060194741-A1 Dimeric IAP inhibitors MEDIVIR AB (SE) 2006-08-31 US disclosed
WO-2006091972-A2 DIMERIC IAP INHIBITORS TETRALOGIC PHARMACEUTICALS (US) 2006-08-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12539336-B2 Antibody, linkers, payload, conjugates and applications thereof IGLV6-57, IGSF11, VSIG8 RXFP1 813/4885HDAC1 4881/4885CA1 4764/4885
US-20250064953-A1 Antibody, Linkers, Payload, Conjugates and Applications Thereof CD47, FCGR2A, CD22 RXFP1 2412/4885HDAC1 3472/4885CA1 2466/4885
US-20080020986-A1 DIMERIC IAP INHIBITORS BIRC2, BIRC7, BIRC8 RXFP1 3282/4885HDAC1 1560/4885CA1 2399/4885
US-20260115305-A1 LINKERS, CONJUGATES AND APPLICATIONS THEREOF CLTB, DCLRE1A, FCGRT RXFP1 603/4885HDAC1 692/4885CA1 482/4885
US-20240327416-A1 Further Substituted Triazolo Quinoxaline Derivatives NR3C1, GRK5, NR3C2 RXFP1 1189/4885HDAC1 785/4885CA1 3720/4885
US-20060194741-A1 Dimeric IAP inhibitors BIRC2, BIRC3, BIRC5 RXFP1 3290/4885HDAC1 911/4885CA1 1495/4885
US-20250387505-A1 ANTI-FGFR3 ANTIBODY CONJUGATE AND MEDICAL USE THEREOF FGFR3, IGSF11, IDUA RXFP1 669/4885HDAC1 4291/4885CA1 2117/4885
US-20250064957-A1 EXATECAN DERIVATIVES, LINKER-PAYLOADS, AND CONJUGATES AND THEREOF XPOT, ENGASE, ENTPD8 RXFP1 1486/4885HDAC1 1127/4885CA1 3542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.