Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715694 | 0.83 | MAPT (0.63) | HSD17B10ALDH1A1GPR35TSHRMAPK1 | |
| SCHEMBL3760791 | 0.81 | ALDH1A1 (0.58) | HSD17B10GFERALDH1A1TSHRPOLB | |
| SCHEMBL7682880 | 0.76 | ABCB11 (0.67) | — | |
| SCHEMBL3756685 | 0.74 | POLB (0.68) | HSD17B10ALDH1A1TSHRMAPK1POLB | |
| SCHEMBL21900171 | 0.72 | MAPT (0.64) | HSD17B10ALDH1A1TSHRPOLBKDM4E | |
| SCHEMBL16111046 | 0.69 | TSHR (0.67) | HSD17B10GFERALDH1A1TSHRMAPK1 | |
| SCHEMBL4957913 | 0.68 | GPR35 (0.50) | HSD17B10ALDH1A1GPR35TSHRPOLB | |
| SCHEMBL9613337 | 0.68 | GPR35 (0.62) | GFERALDH1A1GPR35POLBKDM4E | |
| SCHEMBL8330002 | 0.67 | GPR35 (0.53) | HSD17B10ALDH1A1GPR35TSHRMAPK1 | |
| SCHEMBL14702784 | 0.67 | GPR35 (1.00) | HSD17B10ALDH1A1GPR35POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305093-A1 | Inhibitors of mTOR and Methods of Making and Using | EXELIXIS, INC. (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305093-A1 | Inhibitors of mTOR and Methods of Making and Using | MTOR, RICTOR, RPTOR | HSD17B10 925/4885GFER 3852/4885ALDH1A1 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.