Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | LDHA | P00338 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KMO | O15229 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15630525 | 0.85 | DHODH (0.54) | KEAP1NFE2L2DHODHALDH1A1SMN1; SMN2 | |
| SCHEMBL3758452 | 0.81 | KMO (0.58) | KEAP1NFE2L2ALDH1A1SMN1; SMN2KMO | |
| SCHEMBL29862268 | 0.80 | LDHA (0.47) | KEAP1NFE2L2LDHADHODHSMN1; SMN2 | |
| SCHEMBL17646752 | 0.80 | LDHA (0.47) | KEAP1NFE2L2LDHADHODHSMN1; SMN2 | |
| SCHEMBL10900818 | 0.80 | ALDH1A1 (0.64) | KEAP1NFE2L2LDHADHODHALDH1A1 | |
| SCHEMBL13053992 | 0.79 | NPC1 (0.39) | KEAP1NFE2L2LDHASMN1; SMN2RAB9A | |
| SCHEMBL17498353 | 0.77 | KMO (0.56) | KEAP1NFE2L2DHODHALDH1A1KMO | |
| SCHEMBL7231988 | 0.75 | MAP4K4 (0.37) | LDHAALDH1A1SMN1; SMN2KMOHPGD | |
| SCHEMBL19220973 | 0.75 | SMN1; SMN2 (0.71) | KEAP1NFE2L2DHODHALDH1A1SMN1; SMN2 | |
| SCHEMBL17650473 | 0.74 | KEAP1 (0.49) | KEAP1NFE2L2DHODHALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298221-A1 | 2-PHENOXY NICOTINE ACID DERIVATIVE AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298221-A1 | 2-PHENOXY NICOTINE ACID DERIVATIVE AND USE THEREOF | NAPRT, PNPO, FABP3 | KEAP1 2275/4885NFE2L2 573/4885LDHA 2558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.