Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19220975 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1RXFP1DHODHRAB9A | |
| SCHEMBL10900818 | 0.84 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1RXFP1DHODHRAB9A | |
| SCHEMBL15630525 | 0.83 | DHODH (0.54) | SMN1; SMN2ALDH1A1RXFP1DHODHRAB9A | |
| SCHEMBL17498455 | 0.83 | KDM4E (0.56) | SMN1; SMN2ALDH1A1RXFP1RAB9AMAPT | |
| SCHEMBL11319316 | 0.81 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1RXFP1DHODHRAB9A | |
| SCHEMBL3758452 | 0.79 | KMO (0.58) | SMN1; SMN2ALDH1A1RXFP1RAB9AKEAP1 | |
| SCHEMBL4412318 | 0.77 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1RXFP1DHODHRAB9A | |
| SCHEMBL3753490 | 0.75 | KEAP1 (0.53) | SMN1; SMN2ALDH1A1RXFP1DHODHRAB9A | |
| SCHEMBL27225888 | 0.75 | CASP1 (0.56) | SMN1; SMN2ALDH1A1DHODHAKR1C2AKR1C1 | |
| SCHEMBL30850823 | 0.75 | CASP1 (0.56) | SMN1; SMN2ALDH1A1DHODHAKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170224701-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170224701-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | IDO1, TDO2, IDO2 | SMN1; SMN2 3658/4885ALDH1A1 1167/4885RXFP1 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.