SCHEMBL375538

SCHEMBL375538

NC(=O)C(CCC(F)(F)F)NCCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP2D6 P10635 1/20 0.43
GGT1 P19440 1/20 0.43
MLYCD O95822 2/20 0.42
OPRK1 P41145 1/20 0.40
SIGMAR1 Q99720 2/20 0.40
MAPT P10636 2/20 0.40
ALDH1A1 P00352 2/20 0.40
LMNA P02545 2/20 0.40
GAA P10253 2/20 0.40
KDM4E B2RXH2 1/20 0.40
BLM P54132 1/20 0.40
GFER P55789 1/20 0.40
PMP22 Q01453 1/20 0.40
CA12 O43570 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL374901 0.99 CYP3A4 (0.42) CYP3A4CYP1A2CYP2C9CYP2C19CYP2D6
SCHEMBL30882671 0.86 OPRK1 (0.49) CYP3A4CYP1A2CYP2C9CYP2C19CYP2D6
SCHEMBL30882505 0.86 OPRK1 (0.49) CYP3A4CYP1A2CYP2C9CYP2C19CYP2D6
SCHEMBL10070276 0.85 ALDH1A1 (0.42) ALDH1A1HDAC3RAB9A
SCHEMBL1688370 0.85 ALDH1A1 (0.42) ALDH1A1HDAC3RAB9A
Hydrochloric Acid SCHEMBL30882685 0.85 OPRK1 (0.48) CYP3A4CYP1A2CYP2C9CYP2C19CYP2D6
SCHEMBL2246535 0.82 KEAP1 (0.49) GGT1MAPTALDH1A1HDAC3HDAC4
Trifluoroacetic Acid SCHEMBL30882329 0.81 PLAAT3 (0.44) CYP3A4CYP1A2CYP2C9CYP2C19CYP2D6
SCHEMBL7466905 0.80 CYP3A4 (0.45) CYP3A4CYP1A2CYP2C9CYP2C19CYP2D6
SCHEMBL7466897 0.80 CYP3A4 (0.45) CYP3A4CYP1A2CYP2C9CYP2C19CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408757-A1 NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUNDS INCORPORATING DEUTERIUM AS INHIBITORS OF BETA AMYLOID PEPTIDE PRODUCTION A NOVEL ALPHA-(N-SULFONAMIDO) ACETAMIDE COMPOUND INCORPORATING DEUTERIUM AS INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION Bristol-Myers Squibb Company (US) 2012-01-25 EP disclosed
WO-2010107984-A1 NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUNDS INCORPORATING DEUTERIUM AS INHIBITORS OF BETA AMYLOID PEPTIDE PRODUCTION A NOVEL ALPHA-(N-SULFONAMIDO) ACETAMIDE COMPOUND INCORPORATING DEUTERIUM AS INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2010-09-23 WO disclosed
EP-2205575-A1 A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION Bristol-Myers Squibb Company (US) 2010-07-14 EP disclosed
WO-2009058552-A1 A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2009-05-07 WO disclosed