Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.59 |
| ▸ | FNTB | P49356 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6539989 | 0.89 | FNTA (0.49) | FNTAFNTBTSHRLMNAALDH1A1 | |
| SCHEMBL825414 | 0.89 | LMNA (0.63) | TSHRLMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL6540822 | 0.88 | TAS2R14 (0.57) | FNTAFNTBTSHRLMNATAS2R14 | |
| SCHEMBL149160 | 0.87 | LMNA (0.61) | TSHRLMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL638764 | 0.87 | LMNA (0.61) | TSHRLMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL673623 | 0.87 | LMNA (0.61) | TSHRLMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL672047 | 0.87 | LMNA (0.61) | TSHRLMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL8718249 | 0.87 | LMNA (0.61) | TSHRLMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL14362172 | 0.84 | DPP4 (0.54) | — | |
| Carbamic Acid SCHEMBL6466030 | 0.83 | LMNA (0.57) | TSHRLMNAALDH1A1NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |