SCHEMBL638764

SCHEMBL638764

O=C(O)N(Cc1ccccc1)Cc1ccccc1.[Ni]

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.61
ALDH1A1 P00352 3/20 0.59
NPSR1 Q6W5P4 2/20 0.59
TSHR P16473 1/20 0.57
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
TDP1 Q9NUW8 1/20 0.55
KDM4E B2RXH2 1/20 0.55
MGLL Q99685 1/20 0.54
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
CA12 O43570 1/20 0.52
CA9 Q16790 1/20 0.52
MAPT P10636 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
REN P00797 1/20 0.52
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC10 Q969S8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL825414 0.97 LMNA (0.63) LMNAALDH1A1NPSR1TSHRMEN1
SCHEMBL673623 0.95 LMNA (0.61) LMNAALDH1A1NPSR1TSHRMEN1
SCHEMBL8718249 0.95 LMNA (0.61) LMNAALDH1A1NPSR1TSHRMEN1
SCHEMBL672047 0.95 LMNA (0.61) LMNAALDH1A1NPSR1TSHRMEN1
SCHEMBL149160 0.95 LMNA (0.61) LMNAALDH1A1NPSR1TSHRMEN1
Carbamic Acid SCHEMBL6466030 0.91 LMNA (0.57) LMNAALDH1A1NPSR1TSHRMEN1
SCHEMBL375755 0.87 FNTA (0.59) LMNAALDH1A1NPSR1TSHRMEN1
SCHEMBL7397340 0.86 LMNA (0.57) LMNAALDH1A1NPSR1TSHRMEN1
SCHEMBL9547536 0.85 LMNA (0.73) LMNAALDH1A1NPSR1TSHRMEN1
SCHEMBL4018453 0.85 LOXL2 (0.56) LMNAALDH1A1NPSR1TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3969490-B1 MODIFIED HIGH-CIS POLYBUTADIENE POLYMER, RELATED METHODS AND TIRE COMPONENTS BRIDGESTONE CORP (JP) 2026-03-25 EP disclosed
US-20250389555-A1 MODIFIED HIGH-CIS POLYBUTADIENE POLYMER, RELATED METHODS AND RUBBER COMPOSITIONS BRIDGESTONE AMERICAS TIRE OPERATIONS, LLC (US) 2025-12-25 US disclosed
US-12410263-B2 Modified high-Cis polybutadiene polymer, related methods and rubber compositions BRIDGESTONE AMERICAS TIRE OPERATIONS, LLC (US) 2025-09-09 US disclosed
US-12264232-B2 Modified high-cis polybutadiene polymer, related methods and tire components BRIDGESTONE CORPORATION (JP) 2025-04-01 US disclosed
US-20250066516-A1 HYDROGENATED POLYBUTADIENE POLYMERS AND RUBBER COMPOSITIONS INCORPORATING SAME BRIDGESTONE CORPORATION (JP) 2025-02-27 US disclosed
CN-113825777-B Modified high cis polybutadiene polymers, related methods and tire components 株式会社普利司通 2025-01-28 CN disclosed
EP-4495146-A2 MODIFIED HIGH-CIS POLYBUTADIENE POLYMER, RELATED METHODS AND RUBBER COMPOSITIONS Bridgestone Americas Tire Operations, LLC (US) 2025-01-22 EP disclosed
EP-3966259-B1 MODIFIED HIGH-CIS POLYBUTADIENE POLYMER, RELATED METHODS AND RUBBER COMPOSITIONS BRIDGESTONE AMERICAS TIRE OPERATIONS LLC (US) 2024-10-30 EP disclosed
CN-118574860-A Hydrogenated polybutadiene polymer and rubber composition containing the same 株式会社普利司通 2024-08-30 CN disclosed
CN-113906058-B Modified high cis polybutadiene polymers, related methods and rubber compositions 普利司通美国轮胎运营有限责任公司 2024-05-17 CN disclosed
WO-2011047021-A1 PROCESSES FOR PREPARATION OF CYCLIC ACYCLIC DIENE COPOLYMER AND RUBBER COMPOSITION BRIDGESTONE CORPORATION (JP) 2011-04-21 WO disclosed
US-20100137520-A1 Branched Polymers and Methods for Their Synthesis and Use BRIDGESTONE CORPORATION (JP) 2010-06-03 US disclosed
US-7585805-B2 polymerization catalyst containing e.g.a combination or reaction product of triisobutylaluminum an alkylating agent, Ni(II) neodecanoate borate as nickel compound, trifluoride/n-hexanol complex as F2 compound and tin tetrachloride as Cl2 compound to polymerize 1,3-butadiene to cis-1,4-polybutadiene BRIDGESTONE CORPORATION 2009-09-08 US disclosed
EP-2066735-A2 BRANCHED POLYMERS AND METHODS FOR THEIR SYNTHESIS AND USE Bridgestone Corporation (JP) 2009-06-10 EP disclosed
US-20080255327-A1 addition polymerization of conjugated polyene monomer in the presence of polymerization catalysts comprising a mixture of a nickel-containing compound, an alkylating agent, a fluorine-containing compound, a carboxylic acid and an alcohol; controlling gelation, branching and molecular weight; efficiency BRIDGESTONE CORPORATION (JP) 2008-10-16 US disclosed
WO-2008045372-A2 BRANCHED POLYMERS AND METHODS FOR THEIR SYNTHESIS AND USE BRIDGESTONE CORPORATION (JP) 2008-04-17 WO disclosed
US-20070117942-A1 Nickel-based catalyst composition BRIDGESTONE CORPORATION 2007-05-24 US disclosed
EP-1788003-A1 Nickel-based catalyst composition Bridgestone Corporation (JP) 2007-05-23 EP disclosed
US-6699813-B2 COMPOSITION THAT IS COMBINATION OF OR REACTION PRODUCT OF LANTHANIDE COMPOUND, ALKYLATING AGENT, NICKEL-CONTAINING COMPOUND, AND OPTIONALLY HALOGEN-CONTAINING COMPOUND THAT INCLUDES ONE OR MORE LABILE HALOGEN ATOMS BRIDGESTONE CORPORATION (JP) 2004-03-02 US disclosed
US-20030176276-A1 Lanthanide-based catalyst composition for the manufacture of polydienes BRIDGESTONE CORPORATION (JP) 2003-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250389555-A1 MODIFIED HIGH-CIS POLYBUTADIENE POLYMER, RELATED METHODS AND RUBBER COMPOSITIONS MALT1, INO80C, RTCB LMNA 450/4885ALDH1A1 778/4885NPSR1 4139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.