Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | RXRA | P19793 | 3/20 | 0.64 |
| ▸ | RXRB | P28702 | 3/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.60 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.60 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.56 |
| ▸ | RXRG | P48443 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2705229 | 0.90 | MRGPRX4 (0.65) | HPGDRXRARXRBNR4A2NR4A1 | |
| SCHEMBL1934576 | 0.86 | HPGD (0.70) | HPGDRXRARXRBNR4A2NR4A1 | |
| SCHEMBL13047783 | 0.82 | FFAR1 (0.46) | HPGDRXRARXRBMRGPRX4MEN1 | |
| SCHEMBL1221359 | 0.81 | NR4A2 (0.90) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL6342568 | 0.81 | NR4A2 (0.71) | HPGDRXRARXRBNR4A2NR4A1 | |
| SCHEMBL1881853 | 0.81 | NR4A2 (0.71) | RXRARXRBNR4A2NR4A1NR4A3 | |
| SCHEMBL21327244 | 0.80 | ALOX5 (0.58) | HPGDRXRARXRBMRGPRX4MEN1 | |
| SCHEMBL2705223 | 0.79 | MAOB (0.61) | MRGPRX4 | |
| SCHEMBL1749470 | 0.79 | RXRA (1.00) | HPGDRXRARXRBNR4A2NR4A1 | |
| SCHEMBL9357892 | 0.78 | RHEB (0.44) | HPGDRXRARXRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136940-A1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| US-20100303758-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2010-12-02 | — | — | US | disclosed |
| US-20100303758-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2010-12-02 | — | — | US | disclosed |
| US-20100303758-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100303758-A1 | Novel Glucocorticoid Receptor Agonists | NR3C1, NR3C2, MC2R | HPGD 688/4885RXRA 538/4885RXRB 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.