Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085322 | 0.82 | CCR5 (0.44) | TDP1L3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL3392120 | 0.67 | TDP1 (0.48) | TDP1L3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL27511348 | 0.67 | ALDH1A1 (0.45) | TDP1L3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL977540 | 0.67 | HCAR2 (0.39) | TDP1L3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL977541 | 0.67 | HCAR2 (0.39) | TDP1L3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL14272580 | 0.67 | CCR5 (0.42) | ALDH1A1CCR5KDM4EMAPK14CYP3A4 | |
| SCHEMBL13542937 | 0.67 | CCR5 (0.42) | CCR5MAPK14 | |
| SCHEMBL1935380 | 0.67 | ALDH1A1 (0.48) | TDP1ALDH1A1SMN1; SMN2HSD17B10CYP3A4 | |
| SCHEMBL2940686 | 0.65 | ALDH1A1 (0.47) | TDP1L3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4068248 | 0.64 | CA12 (0.49) | TDP1ALDH1A1SMN1; SMN2CCR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298366-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2010-11-25 | — | — | US | disclosed |
| US-7790747-B2 | Chemokine receptor binding compounds | GENZYME CORPORATION (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090099205-A1 | Chemokine receptor binding compounds | GENZYME CORPORATION | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298366-A1 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | CCR5, CXCR3, CCL5 | TDP1 4502/4885L3MBTL1 3659/4885ALDH1A1 3358/4885 |
| US-20090099205-A1 | Chemokine receptor binding compounds | CCR5, CXCR3, CCL5 | TDP1 4502/4885L3MBTL1 3659/4885ALDH1A1 3358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.