Sugi Predict

Sugi Predict / Compounds / SCHEMBL375913

SCHEMBL375913

SCHEMBL375913

Nc1nc(Cl)c([N+](=O)[O-])s1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.42
▸ MAPT P10636 5/20 0.42
▸ CYP3A4 P08684 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ HPGD P15428 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ GAA P10253 3/20 0.37
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ PKM P14618 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ POLB P06746 1/20 0.33
▸ MGAM O43451 2/20 0.33
▸ SI P14410 2/20 0.33
▸ MGAM2 Q2M2H8 2/20 0.33
▸ CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6509690 0.78 MAPT (0.31) ALDH1A1MAPTHPGDSMN1; SMN2HTT
SCHEMBL9762512 0.78 ALDH1A1 (0.41) ALDH1A1MAPTCYP3A4TSHRTDP1
SCHEMBL10781893 0.77 ALDH1A1 (0.43) ALDH1A1MAPTCYP3A4TSHRTDP1
SCHEMBL17304299 0.75 HTT (0.39) ALDH1A1MAPTHPGDGAASMN1; SMN2
SCHEMBL9788009 0.75 GPR35 (0.31) —
SCHEMBL25063183 0.75 MAPT (0.39) ALDH1A1MAPTCYP3A4TSHRTDP1
SCHEMBL9788022 0.75 GALR2 (0.33) ALDH1A1MAPTHPGDSMN1; SMN2HTT
SCHEMBL958749 0.75 NOS1 (0.46) ALDH1A1MAPTCYP3A4TSHRTDP1
SCHEMBL9788058 0.75 — —
SCHEMBL27671733 0.75 MAPT (0.39) ALDH1A1MAPTCYP3A4TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 — — US disclosed
EP-2632460-B1 THIOPHENE DERIVATIVES FOR USE IN THE TREATMENT OF TUBERCULOSIS UNIV VIRGINIA PATENT FOUNDATION (US) 2018-02-28 — — EP disclosed
US-9376430-B2 Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2016-06-28 — — US disclosed
US-9376430-B2 Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2016-06-28 — — US disclosed
US-9376430-B2 Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2016-06-28 — — US disclosed
US-9333193-B2 Compositions and methods for treating tuberculosis UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2016-05-10 — — US disclosed
US-9333193-B2 Compositions and methods for treating tuberculosis UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2016-05-10 — — US disclosed
US-9333193-B2 Compositions and methods for treating tuberculosis UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2016-05-10 — — US disclosed
US-7513916-B2 Agents for coloring keratin fibers THE PROCTER & GAMBLE COMPANY (US) 2009-04-07 — — US disclosed
US-20070199160-A1 Agents for coloring keratin fibers THE PROCTER & GAMBLE COMPANY 2007-08-30 — — US disclosed
WO-2007097930-A1 AGENTS FOR COLORING KERATIN FIBERS THE PROCTER & GAMBLE COMPANY (US) 2007-08-30 — — WO disclosed
EP-1825883-A1 Agents for coloring keratin fibers Wella Aktiengesellschaft (DE) 2007-08-29 — — EP disclosed
EP-1820537-A1 Agents for coloring keratin fibers Wella Aktiengesellschaft (DE) 2007-08-22 — — EP disclosed
WO-2005014591-A1 2-ACYLAMINO OR 2-SULFONYLAMINO-1, 3-THIAZOLES AS COUPLERS FOR THE OXIDATION DYEING OF KERATIN FIBRES L'OREAL (FR) 2005-02-17 — — WO disclosed
US-5075326-A Fungicides, microbiocides BAYER AKTIENGESELLSCHAFT (DE) 1991-12-24 — — US disclosed
US-5071865-A Fungicides, bactericides BAYER AKTIENGESELLSCHAFT (DE) 1991-12-10 — — US disclosed
EP-0402716-A1 2-Acylamino-4-halogeno-5-nitrothiazole derivatives, process for their preparation, their use in pesticides and new intermediate products BAYER AG (DE) 1990-12-19 — — EP disclosed
US-4962102-A FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 1990-10-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 ALDH1A1 1427/4885MAPT 3010/4885CYP3A4 2625/4885
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 ALDH1A1 1427/4885MAPT 3010/4885CYP3A4 2625/4885
US-20070199160-A1 Agents for coloring keratin fibers KRT18, IK, KRTCAP2 ALDH1A1 1069/4885MAPT 781/4885CYP3A4 3518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.