SCHEMBL376154

SCHEMBL376154

CC(C)(C)OC(=O)[C@H](CCO)NC(=O)OCc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.57
CTSK P43235 9/20 0.54
CTSS P25774 7/20 0.53
CTSL P07711 5/20 0.53
CTSB P07858 3/20 0.53
PPARA Q07869 1/20 0.51
ALDH1A1 P00352 1/20 0.49
ALOX15 P16050 1/20 0.49
KYNU Q16719 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2619553 1.00 SYK (0.57) SYKCTSKCTSSCTSLCTSB
SCHEMBL995705 1.00 SYK (0.57) SYKCTSKCTSSCTSLCTSB
SCHEMBL7222412 0.93 SYK (0.55) SYKCTSKCTSSCTSLCTSB
SCHEMBL5970655 0.93 SYK (0.55) SYKCTSKCTSSCTSLCTSB
SCHEMBL30649083 0.91 SYK (0.54) SYKCTSKCTSSCTSLCTSB
SCHEMBL10166824 0.91 SYK (0.54) SYKCTSKCTSSCTSLCTSB
SCHEMBL14207360 0.90 CTSK (0.63) SYKCTSKCTSSCTSLCTSB
SCHEMBL13205156 0.90 PPARA (0.57) SYKCTSKCTSSCTSLCTSB
SCHEMBL1094804 0.90 PPARA (0.57) SYKCTSKCTSSCTSLCTSB
SCHEMBL1094803 0.90 PPARA (0.57) SYKCTSKCTSSCTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230174562-A1 RADIO-AND CHEMO-PROTECTIVE COMPOUNDS Tonix Pharmaceuticals, Inc. 2023-06-08 US disclosed
US-20230174562-A1 RADIO-AND CHEMO-PROTECTIVE COMPOUNDS Tonix Pharmaceuticals, Inc. 2023-06-08 US disclosed
US-20230174562-A1 RADIO-AND CHEMO-PROTECTIVE COMPOUNDS Tonix Pharmaceuticals, Inc. 2023-06-08 US disclosed
US-20230138150-A1 RADIO-PROTECTIVE AND CHEMO-PROTECTIVE SUBSTITUTED THIOLS Tonix Pharmaceuticals, Inc. 2023-05-04 US disclosed
US-20230138150-A1 RADIO-PROTECTIVE AND CHEMO-PROTECTIVE SUBSTITUTED THIOLS Tonix Pharmaceuticals, Inc. 2023-05-04 US disclosed
US-20230138150-A1 RADIO-PROTECTIVE AND CHEMO-PROTECTIVE SUBSTITUTED THIOLS Tonix Pharmaceuticals, Inc. 2023-05-04 US disclosed
EP-4146662-A1 RADIO-AND CHEMO-PROTECTIVE COMPOUNDS Tonix Pharmaceuticals, Inc. (US) 2023-03-15 EP disclosed
US-11566032-B2 Radio-protective and chemo-protective substituted thiols Tonix Pharmaceuticals, Inc. (US) 2023-01-31 US disclosed
US-11566032-B2 Radio-protective and chemo-protective substituted thiols Tonix Pharmaceuticals, Inc. (US) 2023-01-31 US disclosed
US-20210388011-A1 RADIO-AND CHEMO-PROTECTIVE COMPOUNDS TONIX PHARMACEUTICALS HOLDING CORP. 2021-12-16 US disclosed
US-6602878-B1 Acylquanidine derivatives, method for preparing same, application as medicines and pharmaceutical compositions containing them AVENTIS PHARMA S.A. (FR) 2003-08-05 US disclosed
CN-1101816-C Substituted purine derivatives, their preparation, their use and compositions containing them HOECHST AG (DE) 2003-02-19 CN disclosed
US-6380215-B1 FOR PREVENTION AND/OR TREATMENT OF DISEASES CAUSED BY THROMBUS FORMATION SUCH AS ARTERIAL THROMBOSIS, ARTERIAL SCLEROSIS, ISCHEMIC HEART DISEASES FUJISAWA PHARMACEUTICAL CO., LTD (JP) 2002-04-30 US disclosed
US-20010051730-A1 Beta-alanine derivative and a process for the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-12-13 US disclosed
EP-0669912-B1 N-(3-PIPERIDINYLCARBONYL)-BETA-ALANINE DERIVATIVES AS PAF ANTAGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 2001-12-05 EP disclosed
EP-1106606-A2 N-(3-piperidinylcarbonyl)-beta-alanine derivatives as paf antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-06-13 EP disclosed
CN-1193623-A Substituted purine derivatives, their preparation, their use and compositions containing them HOECHST AG (DE) 1998-09-23 CN disclosed
EP-0853084-A2 Substituted purine derivatives as vitronectin receptor antagonists HOECHST AKTIENGESELLSCHAFT (DE) 1998-07-15 EP disclosed
EP-0669912-A1 N-(3-PIPERIDINYLCARBONYL)-BETA-ALANINE DERIVATIVES AS PAF ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-09-06 EP disclosed
WO-1995008536-A1 N-(3-PIPERIDINYLCARBONYL)-BETA-ALANINE DERIVATIVES AS PAF ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-03-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174562-A1 RADIO-AND CHEMO-PROTECTIVE COMPOUNDS MGMT, RCOR3, TSPO SYK 4867/4885CTSK 1976/4885CTSS 1413/4885
US-20210388011-A1 RADIO-AND CHEMO-PROTECTIVE COMPOUNDS MGMT, GSTP1, GSTA1 SYK 3874/4885CTSK 1439/4885CTSS 664/4885
US-11566032-B2 Radio-protective and chemo-protective substituted thiols MGMT, GSTP1, GSTA1 SYK 3335/4885CTSK 1568/4885CTSS 616/4885
US-20010051730-A1 Beta-alanine derivative and a process for the preparation thereof F13B, FGB, TGFB1 SYK 331/4885CTSK 4338/4885CTSS 4295/4885
US-20230138150-A1 RADIO-PROTECTIVE AND CHEMO-PROTECTIVE SUBSTITUTED THIOLS MGMT, GSTA1, GSTP1 SYK 3259/4885CTSK 2008/4885CTSS 927/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.