Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metronidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.91 |
| ▸ | THRB | P10828 | 1/20 | 0.91 |
| ▸ | TSHR | P16473 | 1/20 | 0.91 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 5/20 | 0.59 |
| ▸ | CA2 | P00918 | 5/20 | 0.59 |
| ▸ | CA9 | Q16790 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 4/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metronidazole SCHEMBL9274611 | 0.97 | LMNA (0.97) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL677157 | 0.95 | LMNA (0.88) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL9481347 | 0.95 | LMNA (1.00) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL9482744 | 0.95 | LMNA (1.00) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL31108924 | 0.95 | LMNA (1.00) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL2221140 | 0.95 | LMNA (1.00) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL5313560 | 0.95 | LMNA (1.00) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL23042 | 0.95 | LMNA (1.00) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL9455119 | 0.95 | LMNA (1.00) | LMNAALDH1A1MAPK1THRBTSHR | |
| Metronidazole SCHEMBL8675069 | 0.94 | LMNA (0.97) | LMNAALDH1A1MAPK1THRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233932-B2 | Oligomer-nitroimidazole anti-infective conjugates | NEKTAR THERAPEUTICS (US) | 2016-01-12 | — | — | US | disclosed |
| US-20140378520-A1 | OLIGOMER-NITROIMIDAZOLE ANTI-INFECTIVE CONJUGATES | NEKTAR THERAPEUTICS | 2014-12-25 | — | — | US | disclosed |
| US-8853247-B2 | Oligomer-nitroimidazole anti-infective conjugates | NEKTAR THERAPEUTICS (US) | 2014-10-07 | — | — | US | disclosed |
| US-20100317707-A1 | Oligomer-Nitroimidazole Anti-Infective Conjugates | NEKTAR THERAPEUTICS (US) | 2010-12-16 | — | — | US | disclosed |
| WO-2009058387-A2 | OLIGOMER-NITROIMIDAZOLE ANTI-INFECTIVE CONJUGATES | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378520-A1 | OLIGOMER-NITROIMIDAZOLE ANTI-INFECTIVE CONJUGATES | NOD2, NOD1, NEDD8 | LMNA 4298/4885ALDH1A1 3342/4885MAPK1 4678/4885 |
| US-20100317707-A1 | Oligomer-Nitroimidazole Anti-Infective Conjugates | NOD2, NOD1, NEDD8 | LMNA 4282/4885ALDH1A1 3411/4885MAPK1 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.