Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 6/20 | 0.40 |
| ▸ | GRK5 | P34947 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.40 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3848594 | 0.99 | ACVR1 (0.44) | ACVR1PIM1PIM3PIM2NCF1 | |
| Hydrochloric Acid SCHEMBL3847440 | 0.84 | CHRM4 (0.47) | ACVR1PIM1PIM3PIM2NCF1 | |
| Hydrochloric Acid SCHEMBL3845869 | 0.81 | DYRK1A (0.55) | ACVR1PIM1PIM3PIM2NCF1 | |
| SCHEMBL3768024 | 0.80 | NCF1 (0.41) | ACVR1PIM1PIM3PIM2NCF1 | |
| Hydrochloric Acid SCHEMBL3853325 | 0.79 | NCF1 (0.40) | ACVR1PIM1PIM3PIM2NCF1 | |
| SCHEMBL30734137 | 0.77 | KCNH2 (0.48) | ACVR1PIM1PIM3PIM2NCF1 | |
| SCHEMBL3761835 | 0.77 | NCF1 (0.58) | ACVR1NCF1 | |
| SCHEMBL3768008 | 0.76 | CHRM4 (0.38) | PIM1PIM3PIM2NCF1 | |
| Hydrochloric Acid SCHEMBL3853437 | 0.75 | CHRM4 (0.38) | PIM1PIM3PIM2NCF1 | |
| SCHEMBL3846401 | 0.74 | ALK (0.36) | ACVR1NCF1LRRK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305065-A1 | USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS | HELPERBY THERAPEUTICS LIMITED (GB) | 2010-12-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305065-A1 | USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS | ARG1, LPO, CTSL | ACVR1 4775/4885PIM1 294/4885PIM3 908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.