Sugi Predict

Sugi Predict / Compounds / SCHEMBL3767736

SCHEMBL3767736

SCHEMBL3767736

N=C(N)SCc1ccc(Cl)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 13/20 1.00
▸ HTT P42858 4/20 1.00
▸ LMNA P02545 2/20 0.64
▸ SMN1; SMN2 Q16637 2/20 0.64
▸ TAAR1 Q96RJ0 2/20 0.64
▸ CYP1A2 P05177 3/20 0.63
▸ PRMT1 Q99873 1/20 0.63
▸ CYP2C9 P11712 2/20 0.62
▸ CYP2D6 P10635 1/20 0.62
▸ HPGD P15428 1/20 0.62
▸ ALOX15 P16050 1/20 0.62
▸ CYP3A4 P08684 1/20 0.58
▸ MAPK1 P28482 1/20 0.58
▸ CYP2C19 P33261 1/20 0.58
▸ EPHX1 P07099 1/20 0.50
▸ MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22275663 0.87 IDO1 (0.77) IDO1HTTLMNASMN1; SMN2TAAR1
SCHEMBL5318320 0.87 IDO1 (0.76) IDO1HTTLMNASMN1; SMN2TAAR1
SCHEMBL13007592 0.86 IDO1 (0.75) IDO1HTTLMNASMN1; SMN2TAAR1
Bromide SCHEMBL22262971 0.86 IDO1 (0.78) IDO1HTTLMNASMN1; SMN2TAAR1
SCHEMBL13256328 0.83 IDO1 (0.71) IDO1HTTLMNASMN1; SMN2TAAR1
SCHEMBL13256341 0.82 IDO1 (0.69) IDO1HTTLMNASMN1; SMN2TAAR1
SCHEMBL15457410 0.82 IDO1 (0.70) IDO1HTTCYP1A2PRMT1CYP2C9
Hydrochloric Acid SCHEMBL3421387 0.81 IDO1 (0.68) IDO1HTTLMNASMN1; SMN2TAAR1
SCHEMBL15457412 0.79 IDO1 (0.66) IDO1HTTLMNACYP1A2CYP2C9
SCHEMBL3752992 0.79 IDO1 (0.66) IDO1HTTLMNASMN1; SMN2TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8642278-B2 Inhibition of cell proliferation UNIVERSITY OF SOUTH FLORIDA (US) 2014-02-04 — — US claimed
US-20060241185-A1 Antibiotics targeting MreB THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2006-10-26 — — US claimed
CN-120324393-B Use of (2, 4-dichlorophenyl) methylthiomethane amidine and salts thereof 广东海洋大学 2025-11-04 — — CN disclosed
CN-120324393-B Use of (2, 4-dichlorophenyl) methylthiomethane amidine and salts thereof 广东海洋大学 2025-11-04 — — CN disclosed
US-20250281607-A1 MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER TORAY INDUSTRIES, INC. (JP) 2025-09-11 — — US disclosed
CN-120324393-A Use of (2, 4-dichlorophenyl) methylthiomethane amidine and salts thereof 广东海洋大学 2025-07-18 — — CN disclosed
CN-120324393-A Use of (2, 4-dichlorophenyl) methylthiomethane amidine and salts thereof 广东海洋大学 2025-07-18 — — CN disclosed
EP-4378478-A1 MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER Toray Industries, Inc. (JP) 2024-06-05 — — EP disclosed
CN-117677398-A Medicine for treating and/or preventing cancer 东丽株式会社 2024-03-08 — — CN disclosed
WO-2023008462-A1 MEDICAMENT FOR TREATMENT AND/OR PREVENTION OF CANCER 東レ株式会社 2023-02-02 — — WO disclosed
US-20190031624-A1 THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION UNIV RUTGERS (US) 2019-01-31 — — US disclosed
US-20100184851-A1 INHIBITION OF CELL PROLIFERATION UNIVERSITY OF SOUTH FLORIDA (US) 2010-07-22 — — US disclosed
WO-2010025448-A2 INHIBITION OF CELL PROLIFERATION UNIVERSITY OF SOUTH FLORIDA (US) 2010-03-04 — — WO disclosed
EP-1962892-A2 INHIBITION OF CELL PROLIFERATION University of South Florida (US) 2008-09-03 — — EP disclosed
US-20070254318-A1 INHIBITION OF CELL PROLIFERATION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-11-01 — — US disclosed
US-20070254318-A1 INHIBITION OF CELL PROLIFERATION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-11-01 — — US disclosed
US-20070254318-A1 INHIBITION OF CELL PROLIFERATION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-11-01 — — US disclosed
WO-2007062222-A2 INHIBITION OF CELL PROLIFERATION UNIVERSITY OF SOUTH FLORIDA (US) 2007-05-31 — — WO disclosed
WO-2007062222-A2 INHIBITION OF CELL PROLIFERATION UNIVERSITY OF SOUTH FLORIDA (US) 2007-05-31 — — WO disclosed
US-20060241185-A1 Antibiotics targeting MreB THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2006-10-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190031624-A1 THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION ABCB11, SLC10A1, SLC47A1 IDO1 3165/4885HTT 4063/4885LMNA 4360/4885
US-20070254318-A1 INHIBITION OF CELL PROLIFERATION RB1, RAF1, NRAS IDO1 4187/4885HTT 4772/4885LMNA 4361/4885
US-20060241185-A1 Antibiotics targeting MreB SMC4, INCENP, DDB1 IDO1 2985/4885HTT 4629/4885LMNA 1934/4885
US-20100184851-A1 INHIBITION OF CELL PROLIFERATION MKI67, RB1, RAF1 IDO1 4276/4885HTT 3856/4885LMNA 3323/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.