Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYTH3 | O43739 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | EPN1 | Q9Y6I3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11401357 | 0.98 | ADORA3 (0.56) | ADORA3MEN1KMT2APOLBMAPT | |
| SCHEMBL1222694 | 0.83 | ALOX15 (0.61) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL71193 | 0.81 | MEN1 (0.51) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL1413998 | 0.81 | KMT2A (0.59) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL18304807 | 0.79 | KMT2A (0.58) | ADORA3KMT2APOLBBRD4KDM4E | |
| SCHEMBL18311756 | 0.78 | ADORA3 (0.45) | ADORA3HCAR2IDO1BRD4KDM4E | |
| SCHEMBL69492 | 0.78 | MEN1 (0.58) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL29930951 | 0.77 | HSD17B10 (0.60) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL71938 | 0.77 | HSD17B10 (0.60) | MEN1KMT2APOLBMAPTHCAR2 | |
| SCHEMBL70810 | 0.77 | KMO (0.55) | MEN1KMT2APOLBMAPTHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842696-B2 | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-30 | — | — | US | claimed |
| US-20090221583-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-03 | — | — | US | claimed |
| WO-2008157844-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-12-24 | — | — | WO | claimed |
| US-7842696-B2 | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-30 | — | — | US | disclosed |
| US-20090221583-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-03 | — | — | US | disclosed |
| WO-2008157844-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-12-24 | — | — | WO | disclosed |
| US-4239896-A | INTERMEDIATES FOR ANTI-ALLERGY COMPOUNDS | E. R. SQUIBB & SONS, INC. (US) | 1980-12-16 | — | — | US | disclosed |
| US-4198412-A | Pyrazolo [1,5-C] quinazoline derivatives and their use in treating allergic conditions | E. R. SQUIBB & SONS, INC. (US) | 1980-04-15 | — | — | US | disclosed |
| US-3899508-A | 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof | LILLY CO ELI | 1975-08-12 | — | — | US | disclosed |
| US-3899508-A | 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof | LILLY CO ELI | 1975-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221583-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | ADORA3 4461/4885MEN1 4883/4885KMT2A 1389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.