Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 18/20 | 0.48 |
| ▸ | MMP3 | P08254 | 9/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3768329 | 1.00 | MMP8 (0.48) | MMP8MMP3POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL5129412 | 0.92 | MMP8 (0.56) | MMP8MMP3POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL5131064 | 0.90 | TAS2R14 (0.58) | MMP8MMP3 | |
| SCHEMBL3818398 | 0.90 | TAS2R14 (0.58) | MMP8MMP3 | |
| SCHEMBL2568805 | 0.88 | ALDH1A1 (0.47) | MMP8MMP3POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL5122805 | 0.87 | BDKRB1 (0.50) | MMP8MMP3POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL5127128 | 0.83 | EPHX2 (0.43) | POLBAPOBEC3AAPOBEC3GTDP1L3MBTL1 | |
| SCHEMBL3813955 | 0.82 | POLB (0.43) | MMP8MMP3POLBTDP1L3MBTL1 | |
| SCHEMBL5121650 | 0.82 | POLB (0.43) | MMP8MMP3POLBTDP1L3MBTL1 | |
| SCHEMBL3763639 | 0.81 | TAS2R14 (0.42) | MMP8MMP3AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435978-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| US-20100324009-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-23 | — | — | US | disclosed |
| US-20100317644-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2010-12-16 | — | — | US | disclosed |
| US-20080153843-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2008-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317644-A1 | Substituted Sulfonamide Compounds | SULT2A1, STS, SULT1A1 | MMP8 2055/4885MMP3 3494/4885POLB 2852/4885 |
| US-20100324009-A1 | Substituted Sulfonamide Compounds | SULT2A1, STS, SULT1A1 | MMP8 2055/4885MMP3 3494/4885POLB 2852/4885 |
| US-20080153843-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | SULT2A1, STS, SULT1A1 | MMP8 2055/4885MMP3 3494/4885POLB 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.