Sugi Predict

Sugi Predict / Compounds / SCHEMBL376895

SCHEMBL376895

SCHEMBL376895

OCc1cc(F)c(Cl)cc1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM1A O60341 2/20 0.39
▸ KDM1B Q8NB78 1/20 0.39
▸ GPR84 Q9NQS5 1/20 0.37
▸ MAPT P10636 3/20 0.35
▸ ALDH1A1 P00352 2/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ TAAR1 Q96RJ0 1/20 0.33
▸ HTR2A P28223 3/20 0.33
▸ SLC6A4 P31645 1/20 0.33
▸ KCNH2 Q12809 1/20 0.33
▸ PDXK O00764 1/20 0.32
▸ HTR2C P28335 2/20 0.32
▸ HTR2B P41595 2/20 0.32
▸ MAPK1 P28482 1/20 0.32
▸ ITGB3 P05106 1/20 0.32
▸ ITGAV P06756 1/20 0.32
▸ MEN1 O00255 1/20 0.31
▸ HTT P42858 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30030883 1.00 KDM1A (0.39) KDM1AKDM1BGPR84MAPTALDH1A1
SCHEMBL14573871 0.91 GPR84 (0.37) KDM1AKDM1BGPR84MAPTALDH1A1
SCHEMBL31618915 0.88 RAB9A (0.35) GPR84MAPTTAAR1PDXKMEN1
SCHEMBL18133874 0.88 RAB9A (0.35) GPR84MAPTTAAR1PDXKMEN1
SCHEMBL6192193 0.86 GPR84 (0.37) KDM1AKDM1BGPR84MAPTALDH1A1
SCHEMBL6301457 0.86 GPR84 (0.37) KDM1AKDM1BGPR84MAPTALDH1A1
SCHEMBL523311 0.84 GRIA1 (0.35) ALDH1A1TDP1MAPK1MEN1KMT2A
SCHEMBL3824032 0.83 POLB (0.33) KDM1AKDM1BGPR84MAPTALDH1A1
SCHEMBL17466151 0.80 CD44 (0.37) ALDH1A1MAPK1GAA
SCHEMBL3367070 0.80 KDM1A (0.37) KDM1AKDM1BGPR84ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570642-B2 GLP-IR modulating compounds GILEAD SCIENCES, INC. (US) 2026-03-10 — — US disclosed
EP-4691554-A2 GLP-1R MODULATING COMPOUNDS Gilead Sciences, Inc. (US) 2026-02-11 — — EP disclosed
EP-4271672-B1 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-12-03 — — EP disclosed
EP-4605394-A1 PYRIMIDINE SGC STIMULATORS Tisento Therapeutics Inc. (US) 2025-08-27 — — EP disclosed
US-20250109148-A1 HETEROCYCLIC GLP-1 AGONISTS SHANGHAI SHOUTI BIOTECHNOLOGY CO., LTD. (CN) 2025-04-03 — — US disclosed
US-20240199589-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. 2024-06-20 — — US disclosed
WO-2024086179-A1 PYRIMIDINE SGC STIMULATORS TISENTO THERAPEUTICS, INC. (US) 2024-04-25 — — WO disclosed
US-11858918-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2024-01-02 — — US disclosed
US-11858918-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2024-01-02 — — US disclosed
US-11858918-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2024-01-02 — — US disclosed
US-20070021634-A1 SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS PFIZER INC 2007-01-25 — — US disclosed
WO-2007010350-A1 SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS PFIZER PRODUCTS INC. (US) 2007-01-25 — — WO disclosed
US-20070021634-A1 SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS PFIZER INC 2007-01-25 — — US disclosed
EP-1084114-B1 ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS PFIZER PROD INC (US) 2004-09-08 — — EP disclosed
US-20030149048-A1 Isothiazole derivatives useful as anticancer agents PFIZER INC. 2003-08-07 — — US disclosed
US-6548526-B2 Isothiazole derivatives useful as anticancer agents PFIZER INC 2003-04-15 — — US disclosed
US-20010020034-A1 Isothiazole derivatives useful as anticancer agents PFIZER, INC. 2001-09-06 — — US disclosed
US-6235764-B1 Isothiazole derivatives useful as anticancer agents PFIZER INC. 2001-05-22 — — US disclosed
EP-1084114-A1 ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS Pfizer Products Inc. (US) 2001-03-21 — — EP disclosed
WO-1999062890-A1 ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS PFIZER PRODUCTS INC. (US) 1999-12-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010020034-A1 Isothiazole derivatives useful as anticancer agents TP53, MCL1, ACIN1 KDM1A 715/4885KDM1B 1155/4885GPR84 4442/4885
US-20250109148-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, GCGR KDM1A 1735/4885KDM1B 2790/4885GPR84 123/4885
US-20030149048-A1 Isothiazole derivatives useful as anticancer agents TP53, MCL1, ACIN1 KDM1A 715/4885KDM1B 1155/4885GPR84 4442/4885
US-20070021634-A1 SYNTHESIS OF THERAPEUTIC DIPHENYL ETHERS DHFR, CYP2F1, EPOR KDM1A 616/4885KDM1B 969/4885GPR84 1661/4885
US-11858918-B2 GLP-1R modulating compounds GLP1R, GIPR, GPR119 KDM1A 2505/4885KDM1B 2638/4885GPR84 107/4885
US-20240199589-A1 GLP-1R MODULATING COMPOUNDS GLP1R, GIPR, GPR119 KDM1A 2505/4885KDM1B 2638/4885GPR84 107/4885
US-12570642-B2 GLP-IR modulating compounds GLP1R, GIPR, GPR119 KDM1A 2564/4885KDM1B 2289/4885GPR84 208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.