SCHEMBL3769074

SCHEMBL3769074

[2H]C([2H])([2H])N1c2ccccc2C(C(=O)Oc2ccccc2)c2ccccc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
EGFR P00533 2/20 0.41
SRC P12931 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
ALDH1A1 P00352 2/20 0.38
BCHE P06276 1/20 0.37
GAA P10253 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
LMNA P02545 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MAPT P10636 2/20 0.36
ELANE P08246 1/20 0.34
SLC6A3 Q01959 1/20 0.34
CHRM2 P08172 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2218308 0.89 HDAC4 (0.55) HDAC4HDAC7HDAC5CYP1A2CYP2C9
SCHEMBL30132855 0.89 HDAC4 (0.55) HDAC4HDAC7HDAC5CYP1A2CYP2C9
SCHEMBL13005780 0.84 HDAC4 (0.57) HDAC4HDAC7HDAC5CYP1A2CYP2C9
SCHEMBL3772600 0.83 HDAC4 (0.55) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL28319597 0.82 HDAC4 (0.48) HDAC4HDAC7HDAC5CYP1A2CYP2C9
SCHEMBL7793810 0.81 HDAC4 (0.50) HDAC4HDAC7HDAC5CYP1A2CYP2C9
SCHEMBL3769010 0.81 HDAC4 (0.51) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7496889 0.80 HDAC4 (0.46) HDAC4HDAC7HDAC5CYP1A2CYP2C9
SCHEMBL2985418 0.79 HDAC4 (0.51) HDAC4HDAC7HDAC5CYP1A2CYP2C9
SCHEMBL7796545 0.79 HDAC4 (0.51) HDAC4HDAC7HDAC5CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3494396-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF Pierce Biotechnology, Inc. (US) 2019-06-12 EP claimed
US-20180043355-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF PIERCE BIOTECHNOLOGY, INC. 2018-02-15 US claimed
WO-2018027004-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF PIERCE BIOTECHNOLOGY, INC. (US) 2018-02-08 WO claimed
US-10722882-B2 Chemiluminescent and fluorescent substrate pads and uses thereof PIERCE BIOTECHNOLOGY, INC. (US) 2020-07-28 US disclosed
EP-3494396-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF Pierce Biotechnology, Inc. (US) 2019-06-12 EP disclosed
US-20180043355-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF PIERCE BIOTECHNOLOGY, INC. 2018-02-15 US disclosed
WO-2018027004-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF PIERCE BIOTECHNOLOGY, INC. (US) 2018-02-08 WO disclosed
US-8822233-B2 Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates GIRI BRIJ PAL (US) 2014-09-02 US disclosed
US-20140121362-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES MICHIGAN DIAGNOSTICS, LLC (US) 2014-05-01 US disclosed
US-20140088297-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES MICHIGAN DIAGNOSTICS, LLC (US) 2014-03-27 US disclosed
US-20140073771-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES MICHIGAN DIAGNOSTICS, LLC (US) 2014-03-13 US disclosed
US-8546150-B2 Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates Michigan Diagnostics, L.L.C. (US) 2013-10-01 US disclosed
US-20100317122-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES GIRI BRIJ PAL 2010-12-16 US disclosed
US-20100317877-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES GIRI BRIJ PAL 2010-12-16 US disclosed
US-20100317122-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES GIRI BRIJ PAL 2010-12-16 US disclosed
US-20100317031-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES GIRI BRIJ PAL 2010-12-16 US disclosed
US-20100317877-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES GIRI BRIJ PAL 2010-12-16 US disclosed
US-20100317031-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES GIRI BRIJ PAL 2010-12-16 US disclosed
US-7781229-B2 water-soluble, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and (1,2)-dioxetanes; used in the detection of antibodies or antigen in biological fluids and for compounds, particularly toxins and contaminants in the environment and food. MICHIGAN DIAGNOSTICS, LLC (US) 2010-08-24 US disclosed
US-20070225498-A1 water-soluble, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and (1,2)-dioxetanes; used in the detection of antibodies or antigen in biological fluids and for compounds, particularly toxins and contaminants in the environment and food. MICHIGAN DIAGNOSTICS, LLC 2007-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140088297-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES DUOX1, XDH, MPO HDAC4 4737/4885HDAC7 4724/4885HDAC5 4405/4885
US-20140121362-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES DUOX1, XDH, MPO HDAC4 4737/4885HDAC7 4724/4885HDAC5 4405/4885
US-20100317877-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES DUOX1, XDH, MPO HDAC4 4679/4885HDAC7 4639/4885HDAC5 4344/4885
US-20070225498-A1 water-soluble, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and (1,2)-dioxetanes; used in the detection of antibodies or antigen in biological fluids and for compounds, particularly toxins and contaminants in the environment and food. BTD, DDT, LPO HDAC4 4743/4885HDAC7 4734/4885HDAC5 4247/4885
US-20100317031-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES DUOX1, XDH, MPO HDAC4 4705/4885HDAC7 4671/4885HDAC5 4366/4885
US-20100317122-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES DUOX1, XDH, LPO HDAC4 4658/4885HDAC7 4616/4885HDAC5 2684/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.