SCHEMBL3772653

SCHEMBL3772653

[2H]c1c([2H])c([2H])c(-c2cccc3c2C(C(=O)O)c2ccccc2N3C)c([2H])c1[2H]

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
EGFR P00533 2/20 0.38
SRC P12931 1/20 0.38
KMT2A Q03164 3/20 0.34
MEN1 O00255 2/20 0.34
LMNA P02545 2/20 0.34
GAA P10253 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
MAPT P10636 1/20 0.34
ALDH1A1 P00352 1/20 0.33
F2 P00734 1/20 0.33
HPGD P15428 1/20 0.33
ATM Q13315 1/20 0.33
TTR P02766 1/20 0.32
LRRK2 Q5S007 1/20 0.30
CCKBR P32239 1/20 0.30
GPR3 P46089 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3775603 0.93 HDAC4 (0.36) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL2218310 0.87 HDAC4 (0.50) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7787066 0.81 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7796571 0.78 HDAC4 (0.46) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL8876764 0.77 HDAC4 (0.43) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7793163 0.76 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL5665141 0.76 HDAC4 (0.44) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL2989515 0.75 HDAC4 (0.66) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL31613807 0.75 HDAC4 (0.66) HDAC4HDAC7HDAC5EGFRSRC
SCHEMBL7752463 0.74 HDAC4 (0.43) HDAC4HDAC7HDAC5EGFRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180043355-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF PIERCE BIOTECHNOLOGY, INC. 2018-02-15 US claimed
US-10722882-B2 Chemiluminescent and fluorescent substrate pads and uses thereof PIERCE BIOTECHNOLOGY, INC. (US) 2020-07-28 US disclosed
EP-3494396-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF Pierce Biotechnology, Inc. (US) 2019-06-12 EP disclosed
US-20180043355-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF PIERCE BIOTECHNOLOGY, INC. 2018-02-15 US disclosed
WO-2018027004-A1 CHEMILUMINESCENT AND FLUORESCENT SUBSTRATE PADS AND USES THEREOF PIERCE BIOTECHNOLOGY, INC. (US) 2018-02-08 WO disclosed
US-8822233-B2 Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates GIRI BRIJ PAL (US) 2014-09-02 US disclosed
US-20140121362-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES MICHIGAN DIAGNOSTICS, LLC (US) 2014-05-01 US disclosed
US-8546150-B2 Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates Michigan Diagnostics, L.L.C. (US) 2013-10-01 US disclosed
US-20100317122-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES GIRI BRIJ PAL 2010-12-16 US disclosed
US-20100317031-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES GIRI BRIJ PAL 2010-12-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140121362-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES DUOX1, XDH, MPO HDAC4 4737/4885HDAC7 4724/4885HDAC5 4405/4885
US-20100317031-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES DUOX1, XDH, MPO HDAC4 4705/4885HDAC7 4671/4885HDAC5 4366/4885
US-20100317122-A1 NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES DUOX1, XDH, LPO HDAC4 4658/4885HDAC7 4616/4885HDAC5 2684/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.