Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778815 | 0.91 | DDB1 (0.49) | HRH3DDB1CRBNACHEUSP30 | |
| SCHEMBL3778811 | 0.91 | DDB1 (0.49) | HRH3DDB1CRBNACHEUSP30 | |
| SCHEMBL3789071 | 0.88 | ALDH1A1 (0.54) | HRH3DDB1CRBNACHEMAP4K4 | |
| SCHEMBL27227503 | 0.83 | GPR119 (0.56) | DDB1CRBNACHEEHMT2USP30 | |
| SCHEMBL30585858 | 0.80 | NOS2 (0.54) | ACHEUSP30 | |
| SCHEMBL18497654 | 0.80 | NOS2 (0.54) | ACHEUSP30 | |
| SCHEMBL3775852 | 0.80 | HSP90AA1 (0.47) | DDB1CRBNEHMT2PIM1PIM2 | |
| SCHEMBL28811197 | 0.79 | USP30 (0.46) | ACHEEHMT2USP30SYK | |
| SCHEMBL17560179 | 0.78 | NOS1 (0.44) | ACHEEHMT2USP30SYK | |
| SCHEMBL16834211 | 0.78 | EHMT2 (0.43) | DDB1CRBNACHEEHMT2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | HRH3 3/4885DDB1 4287/4885CRBN 3889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.